ENSDARG00000076836


Danio rerio
peroxidasegpx4bglutathionebiosynthesisactivitysited-seriesresolvinse-series-resolvinsthioredoxin-likefoldactiveconservedresponseoxidativestressregulationwntsignalingpathwayoxidation-reductionprocesscellularoxidantdetoxificationoxidoreductasesynthesis-eicosatetraenoicacidderivatives

Features
Gene ID: ENSDARG00000076836
  
Biological name :gpx4b
  
Synonyms : glutathione peroxidase 4b / gpx4b
  
Possible biological names infered from orthology : glutathione peroxidase 4 / GPX4 / O70325 / P36969 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 56642138
Gene end: 56655769
  
Corresponding Affymetrix probe sets: Dr.24921.1.S1_at (Zebrafish Array)   NM_001030070_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000103087
Ensembl peptide - ENSDARP00000154635
NCBI entrez gene - 352929     See in Manteia.
RefSeq - NM_001030070
RefSeq Peptide - NP_001025241
swissprot - Q503Y1
ZFIN ID - ZDB-GENE-030410-3
Ensembl - ENSDARG00000076836
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPX4ENSGALG00000002595Gallus gallus
 GPX4ENSG00000167468Homo sapiens
 Gpx4ENSMUSG00000075706Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gpx4a / glutathione peroxidase 4aENSDARG0000006847878
gpx3 / glutathione peroxidase 3 / GPX6* / GPX5* / P46412* / Q91WR8* / P59796* / O75715* / P21765* / P22352* / glutathione peroxidase 6* / glutathione peroxidase 5* / Epididymal secretory gl...ENSDARG0000004334237
gpx1a / glutathione peroxidase 1a / GPX2* / P18283* / glutathione peroxidase 2*ENSDARG0000001814635
gpx7 / glutathione peroxidase 7 / Q96SL4*ENSDARG0000009151135
gpx8 / glutathione peroxidase 8 (putative) / Q8TED1*ENSDARG0000001330234
gpx1b / glutathione peroxidase 1b / GPX2* / P18283* / glutathione peroxidase 2*ENSDARG0000000620728
si:ch73-111m19.2ENSDARG0000000307725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR012336  Thioredoxin-like fold
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site


Gene Ontology (GO)
response to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stresscell communicationcellular response to stimulusoxidation-reduction processresponse to chemicalresponse to stressresponse to stresscell communicationcell communicationcellular response to stimulucellular response to stimulusoxidation-reduction processoxidation-reduction processresponse to chemicalresponse to chemical
oxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activity
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 12-eicosatetraenoic acid derivatives
Biosynthesis of D-series resolvins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0001058 caudal fin caudal fin decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism dorsal region increased distribution , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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