ENSDARG00000093079


Danio rerio

Features
Gene ID: ENSDARG00000093079
  
Biological name :proca
  
Synonyms : proca / protein C (inactivator of coagulation factors Va and VIIIa), a
  
Possible biological names infered from orthology : P04070 / P33587 / PROC / protein C, inactivator of coagulation factors Va and VIIIa / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 5457388
Gene end: 5475921
  
Corresponding Affymetrix probe sets: Dr.25776.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000119453
Ensembl peptide - ENSDARP00000138595
swissprot - A8KC28
swissprot - B8JLG2
swissprot - F1R2A5
ZFIN ID - ZDB-GENE-060824-5
Ensembl - ENSDARG00000093079
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PROCENSGALG00000001780Gallus gallus
 PROCENSG00000115718Homo sapiens
 ProcENSMUSG00000024386Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG00000038258100
f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000001009737
CABZ01044048.1ENSDARG0000001146336
f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000002949336
f7 / coagulation factor VII / P08709* / P70375* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000003486236
f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*ENSDARG0000008858136
f7i / coagulation factor VIIi / F7* / P70375* / P08709* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000007582735
zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000010078235
proza / protein Z, vitamin K-dependent plasma glycoprotein a / PROZ* / P22891* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000003778330
masp2 / mannan-binding lectin serine peptidase 2 / O00187* / Q91WP0* / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine p...ENSDARG0000000798828
prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000007690027
masp1 / mannan-binding lectin serine peptidase 1 / P48740* / P98064* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA.*ENSDARG0000006872626
c1r / complement component 1, r subcomponent / C1S* / P09871* / complement C1s*ENSDARG0000010024825
pamr1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSDARG0000009348021
si:ch211-102l7.3 / PAMR1 (1 of many) / PAMR1* / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 * / peptidase domain containing associated with muscle regeneration 1*ENSDARG0000010318421
wu:fd46c06 / C1S* / P09871* / complement C1s*ENSDARG0000010209419
hp / haptoglobin / HPR* / P00738* / P00739* / Q61646* / haptoglobin-related protein* / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain*ENSDARG0000005189016
c1s / complement component 1, s subcomponentENSDARG000001005999


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0030195 negative regulation of blood coagulation IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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