ENSDARG00000068726


Danio rerio

Features
Gene ID: ENSDARG00000068726
  
Biological name :masp1
  
Synonyms : mannan-binding lectin serine peptidase 1 / masp1
  
Possible biological names infered from orthology : Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740 / P98064
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 36187434
Gene end: 36223417
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000129578
Ensembl peptide - ENSDARP00000152325
Ensembl peptide - ENSDARP00000090275
Ensembl peptide - ENSDARP00000127666
NCBI entrez gene - 100002060     See in Manteia.
swissprot - E7FDS3
swissprot - X1WBS4
swissprot - X1WH68
ZFIN ID - ZDB-GENE-110421-4
Ensembl - ENSDARG00000068726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MASP1ENSGALG00000007419Gallus gallus
 MASP1ENSG00000127241Homo sapiens
 Masp1ENSMUSG00000022887Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
masp2 / mannan-binding lectin serine peptidase 2 / O00187* / Q91WP0* / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine p...ENSDARG0000000798839
c1r / complement component 1, r subcomponent / C1S* / P09871* / complement C1s*ENSDARG0000010024831
pamr1 / peptidase domain containing associated with muscle regeneration 1 / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 *ENSDARG0000009348019
wu:fd46c06 / C1S* / P09871* / complement C1s*ENSDARG0000010209419
CABZ01044048.1ENSDARG0000001146318
f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000001009717
c1s / complement component 1, s subcomponentENSDARG0000010059917
zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000010078217
si:ch211-102l7.3 / PAMR1 (1 of many) / PAMR1* / Q6UXH9* / Q8BU25* / Inactive serine protease PAMR1 * / peptidase domain containing associated with muscle regeneration 1*ENSDARG0000010318417
f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*ENSDARG0000002949316
f7 / coagulation factor VII / P08709* / P70375* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000003486216
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG0000003825816
f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*ENSDARG0000008858116
proca / protein C (inactivator of coagulation factors Va and VIIIa), a / PROC* / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protei...ENSDARG0000009307916
f7i / coagulation factor VIIi / F7* / P70375* / P08709* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*ENSDARG0000007582715
proza / protein Z, vitamin K-dependent plasma glycoprotein a / PROZ* / P22891* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000003778312
hp / haptoglobin / HPR* / P00738* / P00739* / Q61646* / haptoglobin-related protein* / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain*ENSDARG0000005189010
prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*ENSDARG0000007690010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001867 complement activation, lectin pathway IBA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Lectin pathway of complement activation
Initial triggering of complement
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain edematous , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001094 whole organism whole organism increased curvature , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001161 pectoral fin pectoral fin aplastic , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased length , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage malformed , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage malformed , abnormal
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 ZFA:0001648 cardiac neural crest cardiac neural crest increased amount , abnormal
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 ZFA:0009090 pigment cell pigment cell spatial pattern , abnormal
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 ZFA:0009165 neural crest cell neural crest cell mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000015065 c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...  / reaction
 ENSDARG00000068726 masp1 / mannan-binding lectin serine peptidase 1 / P48740* / P98064* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA.*  / complex
 ENSDARG00000104752 COLEC10 / si:ch211-93i7.4 / Q8CF98* / Q9Y6Z7* / Collectin-10 * / collectin subfamily member 10*  / complex






 

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