ENSDARG00000015065


Danio rerio

Features
Gene ID: ENSDARG00000015065
  
Biological name :c4
  
Synonyms : c4 / complement component 4
  
Possible biological names infered from orthology : C4A / C4B / complement C4A (Rodgers blood group) / complement C4B (Chido blood group) / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / P01029 / P0C0L4 / P0C0L5
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 32351886
Gene end: 32383529
  
Corresponding Affymetrix probe sets: Dr.18997.1.A1_at (Zebrafish Array)   Dr.6623.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000031658
Ensembl peptide - ENSDARP00000127726
Ensembl peptide - ENSDARP00000151959
NCBI entrez gene - 566261     See in Manteia.
RefSeq - XM_005157372
swissprot - F1Q4X5
swissprot - X1WBY4
ZFIN ID - ZDB-GENE-030131-5697
Ensembl - ENSDARG00000015065
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000017040Gallus gallus
 C4AENSG00000244731Homo sapiens
 C4BENSG00000224389Homo sapiens
 C4bENSMUSG00000073418Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-8k3.2ENSDARG0000003842431
c3a.1 / complement component c3a, duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000001269428
c3a.3 / complement component c3a, duplicate 3 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000005220728
c3a.2 / complement component c3a, duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000008735928
c3a.6 / complement component c3a, duplicate 6 / C3* / P01024* / complement C3*ENSDARG0000004371927
c3a.4 / complement component c3a, duplicate 4 / C3* / P01024* / complement C3*ENSDARG0000009319827
c3b.2 / complement component c3b, tandem duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000000181825
c5 / complement component 5 / P01031* / complement C5*ENSDARG0000002100425
c3b.1 / complement component c3b, tandem duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000009306825
si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004168519
sb:cb37 / si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004164518
a2ml / alpha-2-macroglobulin-like / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000005631418
cpamd8 / C3 and PZP-like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSDARG0000005653018
si:ch211-212c13.10 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000009319918
si:dkey-46g23.5 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000000883517
zgc:165518 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007573717
zgc:165453 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007818317
zgc:171445 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011520517
si:dkey-46g23.2 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011581717
zgc:171446 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011600517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Activation of C3 and C5
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044613 c1qa / complement component 1, q subcomponent, A chain / P02745* / P98086* / complement C1q A chain* / Complement C1q subcomponent subunit A *  / reaction
 ENSDARG00000015065 c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...  / complex / reaction
 ENSDARG00000021004 c5 / complement component 5 / P01031* / complement C5*  / reaction
 ENSDARG00000068726 masp1 / mannan-binding lectin serine peptidase 1 / P48740* / P98064* / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA.*  / reaction
 ENSDARG00000100248 c1r / complement component 1, r subcomponent / C1S* / P09871* / complement C1s*  / reaction
 ENSDARG00000104752 COLEC10 / si:ch211-93i7.4 / Q8CF98* / Q9Y6Z7* / Collectin-10 * / collectin subfamily member 10*  / reaction






 

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