ENSMUSG00000073418


Mus musculus

Features
Gene ID: ENSMUSG00000073418
  
Biological name :C4b
  
Synonyms : C4b / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / P01029
  
Possible biological names infered from orthology : C4A / complement C4A (Rodgers blood group) / complement C4B (Chido blood group) / P0C0L4 / P0C0L5
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34728380
Gene end: 34743882
  
Corresponding Affymetrix probe sets: 10450242 (MoGene1.0st)   1418021_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069418
Ensembl peptide - ENSMUSP00000134611
NCBI entrez gene - 12268     See in Manteia.
MGI - MGI:88228
RefSeq - XM_006523532
RefSeq - NM_009780
RefSeq - XM_006523531
RefSeq Peptide - NP_033910
swissprot - P01029
swissprot - G3UZS2
Ensembl - ENSMUSG00000073418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c4ENSDARG00000015065Danio rerio
 C4ENSGALG00000032231Gallus gallus
 C4AENSG00000244731Homo sapiens
 C4BENSG00000224389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...ENSMUSG0000002416426
Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*ENSMUSG0000002687424
A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*ENSMUSG0000003011119
Pzp / Q61838 / Pregnancy zone protein Alpha-2-macroglobulin 165 kDa subunit Alpha-2-macroglobulin 35 kDa subunitENSMUSG0000003035919
Cd109 / Q8R422 / CD109 antigen / Q6YHK3* / CD109 molecule*ENSMUSG0000004618619
Mug2 / P28666 / Murinoglobulin-2 ENSMUSG0000003013117
A2ml1 / Q3UU35 / alpha-2-macroglobulin like 1ENSMUSG0000004722817
Mug1 / P28665 / Murinoglobulin-1 ENSMUSG0000005990817
Gm7298ENSMUSG0000010802217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR001840  Anaphylatoxin, complement system domain
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily
 IPR037569  Complement component C4-A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006956 complement activation IMP
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0044216 other organism cell ISO
 cellular_componentGO:0045202 synapse ISO
 molecular_functionGO:0001848 complement binding ISO
 molecular_functionGO:0001849 complement component C1q binding ISO
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030246 carbohydrate binding ISO


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Activation of C3 and C5
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Frem1tm1Ksek/Frem1+
Genetic Background: involves: 129 * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
Show

Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024863 Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*  / reaction
 ENSMUSG00000026399 Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*  / complex / reaction
 ENSMUSG00000036655 Colec11 / collectin subfamily member 11 / Q9BWP8*  / reaction
 ENSMUSG00000038591 Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*  / reaction
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / complex / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / complex / reaction
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / complex / reaction
 ENSMUSG00000058952 Cfi / Q61129 / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156* / AC126283.2* / complement factor I*  / complex / reaction
 ENSMUSG00000026401 Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*  / complex / reaction
 ENSMUSG00000016493 Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*  / complex / reaction
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / reaction
 ENSMUSG00000079343 C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*  / reaction
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / reaction
 ENSMUSG00000028979 Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...  / reaction
 ENSMUSG00000055172 C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*  / reaction
 ENSMUSG00000022887 Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*  / reaction
 ENSMUSG00000038521 C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*  / reaction
 ENSMUSG00000098470 C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr