ENSMUSG00000024371


Mus musculus

Features
Gene ID: ENSMUSG00000024371
  
Biological name :C2
  
Synonyms : C2 / Complement C2 Complement C2b fragment Complement C2a fragment / P21180
  
Possible biological names infered from orthology : complement C2 / P06681
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34862604
Gene end: 34898265
  
Corresponding Affymetrix probe sets: 10450344 (MoGene1.0st)   1416051_at (Mouse Genome 430 2.0 Array)   1441912_x_at (Mouse Genome 430 2.0 Array)   1457664_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114241
Ensembl peptide - ENSMUSP00000123536
Ensembl peptide - ENSMUSP00000120009
Ensembl peptide - ENSMUSP00000025230
NCBI entrez gene - 12263     See in Manteia.
MGI - MGI:88226
RefSeq - NM_013484
RefSeq Peptide - NP_038512
swissprot - B8JJM9
swissprot - F6ZCY7
swissprot - B8JJN2
swissprot - P21180
Ensembl - ENSMUSG00000024371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-280e3.1ENSDARG00000019772Danio rerio
 C2ENSGALG00000035721Gallus gallus
 C2ENSG00000166278Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20547 / CFB* / P00751* / AL645922.1* / complement factor B*ENSMUSG0000009251139
Cfb / P04186 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P00751* / AL645922.1* / complement factor B*ENSMUSG0000009023138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002035  von Willebrand factor, type A
 IPR009003  Peptidase S1, PA clan
 IPR011360  Complement B/C2
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037568  Complement C2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006956 complement activation ISO
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:2000427 positive regulation of apoptotic cell clearance IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Activation of C3 and C5
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / complex / reaction
 ENSMUSG00000024863 Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*  / reaction
 ENSMUSG00000026399 Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*  / complex / reaction
 ENSMUSG00000036655 Colec11 / collectin subfamily member 11 / Q9BWP8*  / reaction
 ENSMUSG00000038591 Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*  / reaction
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / reaction
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / complex / reaction
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / reaction
 ENSMUSG00000079343 C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*  / reaction
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / reaction
 ENSMUSG00000028979 Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...  / reaction
 ENSMUSG00000055172 C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*  / reaction
 ENSMUSG00000022887 Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*  / reaction
 ENSMUSG00000026401 Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*  / complex / reaction
 ENSMUSG00000038521 C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*  / reaction
 ENSMUSG00000098470 C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*  / reaction






 

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