ENSMUSG00000036887


Mus musculus

Features
Gene ID: ENSMUSG00000036887
  
Biological name :C1qa
  
Synonyms : C1qa / Complement C1q subcomponent subunit A / P98086
  
Possible biological names infered from orthology : complement C1q A chain / P02745
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 136895917
Gene end: 136898803
  
Corresponding Affymetrix probe sets: 10517517 (MoGene1.0st)   1417381_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048836
NCBI entrez gene - 12259     See in Manteia.
MGI - MGI:88223
RefSeq - NM_007572
RefSeq Peptide - NP_031598
swissprot - P98086
Ensembl - ENSMUSG00000036887
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c1qaENSDARG00000044613Danio rerio
 C1QAENSGALG00000021569Gallus gallus
 C1QAENSG00000173372Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6IR41 / C1qtnf6 / Complement C1q tumor necrosis factor-related protein 6 / Q9BXI9* / C1q and TNF related 6*ENSMUSG0000002244024
Q9QXP7 / C1qtnf1 / Complement C1q tumor necrosis factor-related protein 1 / Q9BXJ1* / C1q and TNF related 1*ENSMUSG0000001744623
Q8R066 / C1qtnf4 / Complement C1q tumor necrosis factor-related protein 4 / Q9BXJ3* / C1q and TNF related 4*ENSMUSG0000004079420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR037572  Complement C1q subcomponent subunit A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IMP
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxc4tm1Hsu/Hoxc4tm1Hsu
Genetic Background: involves: 129S/SvEv * A/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16129S6/SvEvTac
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle18C57BL/6/Sle18C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle18C57BL/6/Sle18C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/?,Sle18C57BL/6/Sle18C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle19C57BL/6/?
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle19C57BL/6/?
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16129S6/SvEvTac
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle18C57BL/6/Sle18C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle18C57BL/6/Sle18C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/?,Sle18C57BL/6/Sle18C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle19C57BL/6/?
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle19C57BL/6/?
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16129S6/SvEvTac
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle16129S6/SvEvTac/Sle16C57BL/6
Genetic Background: involves: 129S/SvEv * 129X1/Sv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

Allelic Composition: C1qatm1Mjw/C1qatm1Mjw,Sle21129P2/Ola/Sle21C57BL/6
Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bbs7tm1b(EUCOMM)Wtsi/Bbs7tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Bbs7tm1b(EUCOMM)Wtsi/J

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Galctwi/Galctwi
Genetic Background: involves: C57BL/6J * CAST/EiJ * CE/J

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023224 P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*  / complex / reaction
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / reaction
 ENSMUSG00000037942 Crp / P14847 / C-reactive protein / P02741*  / complex
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / complex
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / reaction
 ENSMUSG00000079343 C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*  / complex
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / complex
 ENSMUSG00000055172 C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*  / complex
 ENSMUSG00000038521 C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*  / complex
 ENSMUSG00000098470 C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*  / complex
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / complex






 

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