ENSMUSG00000098470


Mus musculus
domainC1rbcomplementsiteegf-likepeptidaseactivityserinesushiscrccpcubproteasestrypsinsfamilycalcium-bindingconservedsuperfamilyimmuneactivationclassicalserine-typeegf-typeaspartateasparaginehydroxylationchymotrypsinpaclanactive

Features
Gene ID: ENSMUSG00000098470
  
Biological name :C1rb
  
Synonyms : C1rb / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / Q8CFG9
  
Possible biological names infered from orthology : C1R / complement C1r / P00736
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 124570294
Gene end: 124581171
  
Corresponding Affymetrix probe sets: 10541683 (MoGene1.0st)   1417009_at (Mouse Genome 430 2.0 Array)   1456437_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139376
NCBI entrez gene - 667277     See in Manteia.
MGI - MGI:3779804
RefSeq - NM_001113356
RefSeq Peptide - NP_001106827
swissprot - Q8CFG9
Ensembl - ENSMUSG00000098470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000014659Gallus gallus
 C1RENSG00000159403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000005517296
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...ENSMUSG0000002897940
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*ENSMUSG0000002288737
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*ENSMUSG0000007934336
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*ENSMUSG0000003852135
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*ENSMUSG0000003852733
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*ENSMUSG0000002718820
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*ENSMUSG0000003113819
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*ENSMUSG0000003144419
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...ENSMUSG0000002438618
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*ENSMUSG0000003144317
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*ENSMUSG0000003172216
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*ENSMUSG0000003144513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035707  Complement subcomponent C1r
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processimmune responseimmune effector processresponse to stressnitrogen compound metabnitrogen compound metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processimmune responseimmune responseimmune effector processimmune effector processresponse to stressresponse to stress
catalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activityion bindingion binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023224 P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*  / complex / reaction
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / complex
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / complex
 ENSMUSG00000079343 C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*  / complex
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / complex
 ENSMUSG00000055172 C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*  / complex
 ENSMUSG00000038521 C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*  / complex
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / reaction
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / reaction
 ENSMUSG00000098470 C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*  / complex






 

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