ENSMUSG00000031443


Mus musculus

Features
Gene ID: ENSMUSG00000031443
  
Biological name :F7
  
Synonyms : Coagulation factor VII Factor VII light chain Factor VII heavy chain / F7 / P70375
  
Possible biological names infered from orthology : coagulation factor VII / P08709
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 13026034
Gene end: 13035809
  
Corresponding Affymetrix probe sets: 10570280 (MoGene1.0st)   1419321_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033820
NCBI entrez gene - 14068     See in Manteia.
MGI - MGI:109325
RefSeq - NM_010172
RefSeq Peptide - NP_034302
swissprot - P70375
swissprot - Q542C2
Ensembl - ENSMUSG00000031443
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f7ENSDARG00000034862Danio rerio
 f7iENSDARG00000075827Danio rerio
 zgc:163025ENSDARG00000100782Danio rerio
 F7ENSGALG00000016833Gallus gallus
 F7ENSG00000057593Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*ENSMUSG0000003144442
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*ENSMUSG0000003113841
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...ENSMUSG0000002438638
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*ENSMUSG0000002288728
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000005517228
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000009847028
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*ENSMUSG0000003144527
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...ENSMUSG0000002897926
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*ENSMUSG0000002718825
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*ENSMUSG0000007934325
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*ENSMUSG0000003852124
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*ENSMUSG0000003852721
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*ENSMUSG0000003172216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR012224  Peptidase S1A, coagulation factor VII/IX/X/C/Z
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR033190  Coagulation factor VII
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation ISO
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010037 response to carbon dioxide IEA
 biological_processGO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032571 response to vitamin K IEA
 biological_processGO:0033595 response to genistein IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0061476 response to anticoagulant IEA
 biological_processGO:0070723 response to cholesterol IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0097068 response to thyroxine IEA
 biological_processGO:1904400 response to Thyroid stimulating hormone IEA
 biological_processGO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine IEA
 biological_processGO:1905217 response to astaxanthin IEA
 biological_processGO:1905225 response to thyrotropin-releasing hormone IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:1905286 serine-type peptidase complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Extrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: F7tm1(tTA,tetO-F7)Edr/F7tm1(tTA,tetO-F7)Edr
Genetic Background: B6.129X1-F7tm1(tTA,tetO-F7)Edr

Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F7tm1(tTA,tetO-F7)Edr/F7tm1(tTA,tetO-F7)Edr
Genetic Background: B6.129X1-F7tm1(tTA,tetO-F7)Edr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdctm1Get/Prkdctm1Get,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: F7tm1(tTA,tetO-F7)Edr/F7tm1(tTA,tetO-F7)Edr
Genetic Background: B6.129X1-F7tm1(tTA,tetO-F7)Edr

Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: F7tm1(tTA,tetO-F7)Edr/F7tm1(tTA,tetO-F7)Edr
Genetic Background: B6.129X1-F7tm1(tTA,tetO-F7)Edr

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: F7tm1(tTA,tetO-F7)Edr/F7tm1(tTA,tetO-F7)Edr
Genetic Background: B6.129X1-F7tm1(tTA,tetO-F7)Edr

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: F7tm1Pec/F7+,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: F7tm1Pec/F7+,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Il1rntm1Nick/Il1rntm1Nick
Genetic Background: involves: BALB/cAnNHsd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031443 F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*  / complex
 ENSMUSG00000028128 F3 / coagulation factor III, tissue factor / P13726*  / complex / reaction
 ENSMUSG00000027082 Tfpi / O54819 / tissue factor pathway inhibitor / P10646*  / complex / reaction
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / complex / reaction
 ENSMUSG00000053460 Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase / P38435* / gamma-glutamyl carboxylase*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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