ENSMUSG00000016493


Mus musculus

Features
Gene ID: ENSMUSG00000016493
  
Biological name :Cd46
  
Synonyms : Cd46 / Membrane cofactor protein / O88174
  
Possible biological names infered from orthology : CD46 molecule / P15529
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 195036826
Gene end: 195092249
  
Corresponding Affymetrix probe sets: 10361270 (MoGene1.0st)   1421586_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123901
Ensembl peptide - ENSMUSP00000123931
NCBI entrez gene - 17221     See in Manteia.
MGI - MGI:1203290
RefSeq - XM_006497239
RefSeq - NM_010778
RefSeq - XM_006497235
RefSeq - XM_006497236
RefSeq - XM_006497237
RefSeq - XM_006497234
RefSeq Peptide - NP_034908
swissprot - O88174
swissprot - A0A0R4J1X9
Ensembl - ENSMUSG00000016493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rca2.1ENSDARG00000056075Danio rerio
 rca2.2ENSDARG00000095512Danio rerio
 C4BPAENSGALG00000001175Gallus gallus
 CD46ENSG00000117335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zp3r / zona pellucida 3 receptorENSMUSG0000004255424
C4bp / P08607 / C4b-binding protein ENSMUSG0000002640522
Cfh / P06909 / Complement factor H / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H related 4* / complement factor H related 3*ENSMUSG0000002636520
Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002639920
Apoh / Q01339 / Beta-2-glycoprotein 1 / P02749* / apolipoprotein H*ENSMUSG0000000004919
Selp / Q01102 / selectin, platelet / P16109* / selectin P*ENSMUSG0000002658019
Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002640118
Gm4788 / complement factor H-related protein C isoform 2 / CFH* / CFHR4* / CFHR3* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 3* / complement factor ...ENSMUSG0000007059418
F13b / Q07968 / Coagulation factor XIII B chain / P05160*ENSMUSG0000002636816
Sele / selectin, endothelial cell / P16581* / selectin E*ENSMUSG0000002658215
Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*ENSMUSG0000002658113
Cfhr2 / complement factor H-related 2 / CFH* / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 4* / complement factor H related 3*ENSMUSG000000338988
Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*ENSMUSG000000570378


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR017341  Membrane cofactor protein CD46
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002456 T cell mediated immunity ISO
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0008593 regulation of Notch signaling pathway ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0032613 interleukin-10 production ISO
 biological_processGO:0032733 positive regulation of interleukin-10 production ISO
 biological_processGO:0035581 sequestering of extracellular ligand from receptor ISO
 biological_processGO:0042102 positive regulation of T cell proliferation ISO
 biological_processGO:0043382 positive regulation of memory T cell differentiation ISO
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation ISO
 biological_processGO:0071636 positive regulation of transforming growth factor beta production ISO
 cellular_componentGO:0002079 inner acrosomal membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0006238 abnormal choriocapillaris morphology "malformation of the capillaries forming the inner vascular layer of the choroid of the eye" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0011557 increased susceptibility to induced choroid neovascularization "increased rate or amount of new growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [MGI:anna, MGI:mnk]
Show

Allelic Composition: Gt(ROSA)26Sortm2(ITK/Syk)Hjum/Gt(ROSA)26Sor+,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129S6/SvEvTac * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / complex / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / complex / reaction
 ENSMUSG00000058952 Cfi / Q61129 / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156* / AC126283.2* / complement factor I*  / complex / reaction






 

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