ENSMUSG00000026582


Mus musculus

Features
Gene ID: ENSMUSG00000026582
  
Biological name :Sele
  
Synonyms : Sele / selectin, endothelial cell
  
Possible biological names infered from orthology : P16581 / selectin E
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.2
Gene start: 164048234
Gene end: 164057677
  
Corresponding Affymetrix probe sets: 10351182 (MoGene1.0st)   1421712_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027874
NCBI entrez gene - 20339     See in Manteia.
MGI - MGI:98278
RefSeq - XM_017319404
RefSeq - NM_011345
RefSeq - XM_006496715
RefSeq Peptide - NP_035475
swissprot - Q3U5F6
Ensembl - ENSMUSG00000026582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 seleENSDARG00000009123Danio rerio
 SELEENSGALG00000031430Gallus gallus
 SELEENSG00000007908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Selp / Q01102 / selectin, platelet / P16109* / selectin P*ENSMUSG0000002658042
Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*ENSMUSG0000002658125
Cfh / P06909 / Complement factor H / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H related 4* / complement factor H related 3*ENSMUSG0000002636517
Gm4788 / complement factor H-related protein C isoform 2 / CFH* / CFHR4* / CFHR3* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 3* / complement factor ...ENSMUSG0000007059417
F13b / Q07968 / Coagulation factor XIII B chain / P05160*ENSMUSG0000002636816
Zp3r / zona pellucida 3 receptorENSMUSG0000004255413
C4bp / P08607 / C4b-binding protein ENSMUSG0000002640512
Apoh / Q01339 / Beta-2-glycoprotein 1 / P02749* / apolipoprotein H*ENSMUSG0000000004910
Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*ENSMUSG000000164939
Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG000000263999
Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG000000264017
Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*ENSMUSG000000570377
Cfhr2 / complement factor H-related 2 / CFH* / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 4* / complement factor H related 3*ENSMUSG000000338985


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR001881  EGF-like calcium-binding domain
 IPR002396  Selectin superfamily
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033991  Selectin, C-type lectin-like domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0030029 actin filament-based process IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0070492 oligosaccharide binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001411 spinning "compulsive rolling of the body" [J:17123]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntsr1tm1Dgen/Ntsr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Sox10m5C3HeB/FeJ/Sox10m5C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10m5C3HeB/FeJ/Sox10m5C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10m5C3HeB/FeJ/Sox10m5C57BL/6J,Sox10Dom/Sox10Dom
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Seletm1Roml/Seletm1Roml
Genetic Background: involves: 129S1/Sv

Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0002346 abnormal lymph node secondary follicle "anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002351 abnormal cervical lymph node morphology "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Roml/Seletm1Roml
Genetic Background: involves: 129S1/Sv

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic Background: B6.129P2-Kdm3atm1.1Yzha

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Pou4f3tm1Xia/Pou4f3tm1Xia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008623 increased circulating interleukin-3 level "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003316 Glg1 / Q61543 / Golgi apparatus protein 1 / Q92896* / golgi glycoprotein 1*  / complex / reaction
 ENSMUSG00000051457 Spn / P15702 / sialophorin / P16150*  / complex / reaction






 

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