Manteia - Molecule gene

ENSMUSG00000026580

Mus musculus

Features

Gene ID:	ENSMUSG00000026580

Biological name :	Selp

Synonyms :	Q01102 / selectin, platelet / Selp

Possible biological names infered from orthology :	P16109 / selectin P

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H2.2
Gene start:	164115264
Gene end:	164150026

Corresponding Affymetrix probe sets:	10351206 (MoGene1.0st) 1420558_at (Mouse Genome 430 2.0 Array) 1440173_x_at (Mouse Genome 430 2.0 Array) 1449906_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000123924 Ensembl peptide - ENSMUSP00000124231 NCBI entrez gene - 20344 See in Manteia. MGI - MGI:98280 RefSeq - NM_011347 RefSeq Peptide - NP_035477 swissprot - F6TL88 swissprot - Q01102 Ensembl - ENSMUSG00000026580

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
selp	ENSDARG00000042138	Danio rerio
	ENSGALG00000002643	Gallus gallus
SELP	ENSG00000174175	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Sele / selectin, endothelial cell / P16581* / selectin E*	ENSMUSG00000026582	34
Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*	ENSMUSG00000026581	22
Cfh / P06909 / Complement factor H / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H related 4* / complement factor H related 3*	ENSMUSG00000026365	18
F13b / Q07968 / Coagulation factor XIII B chain / P05160*	ENSMUSG00000026368	17
Gm4788 / complement factor H-related protein C isoform 2 / CFH* / CFHR4* / CFHR3* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 3* / complement factor ...	ENSMUSG00000070594	16
C4bp / P08607 / C4b-binding protein	ENSMUSG00000026405	12
Zp3r / zona pellucida 3 receptor	ENSMUSG00000042554	12
Apoh / Q01339 / Beta-2-glycoprotein 1 / P02749* / apolipoprotein H*	ENSMUSG00000000049	9
Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*	ENSMUSG00000016493	9
Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*	ENSMUSG00000026399	8
Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*	ENSMUSG00000026401	7
Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*	ENSMUSG00000057037	6
Cfhr2 / complement factor H-related 2 / CFH* / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 4* / complement factor H related 3*	ENSMUSG00000033898	5

Protein motifs (from Interpro)

Interpro ID	Name
IPR000436	Sushi/SCR/CCP domain
IPR000742	EGF-like domain
IPR001304	C-type lectin-like
IPR001881	EGF-like calcium-binding domain
IPR002396	Selectin superfamily
IPR013032	EGF-like, conserved site
IPR016186	C-type lectin-like/link domain superfamily
IPR016187	C-type lectin fold
IPR018378	C-type lectin, conserved site
IPR033991	Selectin, C-type lectin-like domain
IPR035976	Sushi/SCR/CCP superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002687	positive regulation of leukocyte migration	IMP
biological_process	GO:0006954	inflammatory response	IMP
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP
biological_process	GO:0007159	leukocyte cell-cell adhesion	IEA
biological_process	GO:0010572	positive regulation of platelet activation	IMP
biological_process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IEA
biological_process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA
biological_process	GO:0033623	regulation of integrin activation	IEA
biological_process	GO:0035584	calcium-mediated signaling using intracellular calcium source	IEA
biological_process	GO:0050900	leukocyte migration	IMP
biological_process	GO:0050901	leukocyte tethering or rolling	IEA
biological_process	GO:0071354	cellular response to interleukin-6	ISO
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0031092	platelet alpha granule membrane	IEA
molecular_function	GO:0001530	lipopolysaccharide binding	IEA
molecular_function	GO:0005509	calcium ion binding	ISS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008201	heparin binding	IEA
molecular_function	GO:0030246	carbohydrate binding	IEA
molecular_function	GO:0033691	sialic acid binding	IEA
molecular_function	GO:0042806	fucose binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0048306	calcium-dependent protein binding	IDA
molecular_function	GO:0070492	oligosaccharide binding	IEA

Pathways (from Reactome)

Pathway description

Platelet degranulation

Cell surface interactions at the vascular wall

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000217	abnormal white blood cell count	"anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: either: B6.129S7-Selp^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0000336	decreased mast cell number	"fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hr^m2Btlr/Hr^m2Btlr Genetic Background: C57BL/6J-Hr^m2Btlr
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0001209	spontaneous skin ulceration	"unpredictable appearance of skin lesions, usually with inflammation" [J:65302]	Show Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001411	spinning	"compulsive rolling of the body" [J:17123]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001492	piloerection	"the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lats2^tm1Dgen/Lats2^tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Sox10m5^C3HeB/FeJ/Sox10m5^C57BL/6J,Sox10^Dom/Sox10^Dom Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0001606	impaired hematopoiesis	"atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0001654	hepatic necrosis	"pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Spta1^sph-ha/Spta1^sph-ha Genetic Background: either:(B6.D1-Spta1^sph-ha x WB.D1-Spta1^sph-ha)F1 or (WB.D1-Spta1^sph-ha x B6.D1-Spta1^sph-ha)F1
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001851	eye inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv
MP:0001864	vasculitis	"inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Abca4^tm1Ght/Abca4^tm1Ght Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox10m5^C3HeB/FeJ/Sox10m5^C57BL/6J,Sox10^Dom/Sox10^Dom Genetic Background: involves: C3HeB/FeJ * C57BL/6J Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox10m5^C3HeB/FeJ/Sox10m5^C57BL/6J,Sox10^Dom/Sox10^Dom Genetic Background: involves: C3HeB/FeJ * C57BL/6J
MP:0002346	abnormal lymph node secondary follicle	"anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002351	abnormal cervical lymph node morphology	"anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sele^tm1Roml/Sele^tm1Roml Genetic Background: involves: 129S1/Sv
MP:0002463	abnormal neutrophil physiology	"abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002551	abnormal blood coagulation	"altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abca4^tm1Ght/Abca4^tm1Ght Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0002828	abnormal glomerular capsule	"anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0002942	decreased circulating alanine transaminase level	"decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003135	increased erythrocyte precursors	"greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0003627	abnormal lymphocyte rolling	"anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: either: B6.129S7-Selp^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0003628	abnormal lymphocyte adhesion	"anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0003724	susceptibility to induced arthritis	"more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003799	impaired macrophage migration	"defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0003946	renal necrosis	"pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0004007	abnormal lung vasculature	"malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sell^tm4Hyn/Sell^tm4Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0005087	reduced acute inflammation	"less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]	Show Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005191	head tilt	"condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0005606	increased bleeding time	"greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005616	decreased susceptibility to type IV hypersensitivity reaction	"less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hr^m2Btlr/Hr^m2Btlr Genetic Background: C57BL/6J-Hr^m2Btlr
MP:0006055	abnormal vascular endothelial cell morphology	"malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Abca4^tm1Ght/Abca4^tm1Ght Genetic Background: involves: 129S4/SvJae * BALB/c
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0008111	abnormal granulocyte differentiaton	"atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0008139	fused podocyte foot processes	"coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0008140	podocyte foot process effacement	"thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0008522	abnormal lymph node germinal center	"any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008623	increased circulating interleukin-3 level	"increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0008713	abnormal cytokine level	"deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas
MP:0008719	impaired neutrophil recruitment	"reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Selp^tm2Hyn/Selp^tm2Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sell^tm4Hyn/Sell^tm4Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008720	impaired neutrophil migration	"defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008722	abnormal chemokine secretion	"anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0008723	impaired eosinophil recruitment	"reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Selp^tm2Hyn/Selp^tm2Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0009858	abnormal cellular extravasation	"any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv
MP:0011346	renal tubule atrophy	"acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011353	expanded mesangial matrix	"increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011377	renal glomerulus fibrosis	"formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011453	abnormal glomerular capillary endothelium morphology	"any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011483	renal glomerular synechia	"presence of adhesions (synechiae) between the Bowman s capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman s capsule" [MGI:anna]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011506	glomerular crescent	"formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]	Show Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr
MP:0011514	skin hemorrhage	"bleeding into the skin" [MGI:anna]	Show Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0020332	impaired leukocyte tethering or rolling	"reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww Genetic Background: involves: 129S/SvEv Allelic Composition: Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Selp^tm1Bay/Selp^tm1Bay Genetic Background: either: B6.129S7-Selp^tm1Bay Icam1^tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Sele^tm2Alb/Sele^tm2Alb,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fas^lpr/Fas^lpr,Selp^tm1Bay/Selp^tm1Bay Genetic Background: MRL.Cg-Selp^tm1Bay Fas^lpr Allelic Composition: Selp^tm2Hyn/Selp^tm2Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sell^tm4Hyn/Sell^tm4Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sele^tm1Hyn/Sele^tm1Hyn,Sell^tm1Hyn/Sell^tm1Hyn,Selp^tm1Hyn/Selp^tm1Hyn Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Selp^tm1.1Rpmc/Selp^tm1.1Rpmc Genetic Background: B6.129S1-Selp^tm1.1Rpmc

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr