ENSMUSG00000026581


Mus musculus

Features
Gene ID: ENSMUSG00000026581
  
Biological name :Sell
  
Synonyms : P18337 / selectin, lymphocyte / Sell
  
Possible biological names infered from orthology : P14151 / selectin L
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.2
Gene start: 164061982
Gene end: 164084181
  
Corresponding Affymetrix probe sets: 10351197 (MoGene1.0st)   1419480_at (Mouse Genome 430 2.0 Array)   1419481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142237
Ensembl peptide - ENSMUSP00000027871
Ensembl peptide - ENSMUSP00000095099
Ensembl peptide - ENSMUSP00000141365
NCBI entrez gene - 20343     See in Manteia.
MGI - MGI:98279
RefSeq - XM_006496718
RefSeq - NM_001164059
RefSeq - NM_011346
RefSeq - XM_006496716
RefSeq - XM_006496717
RefSeq Peptide - NP_035476
RefSeq Peptide - NP_001157531
swissprot - Q3TCF3
swissprot - Q3UV83
swissprot - A0A0A6YW25
swissprot - B1B507
swissprot - P18337
Ensembl - ENSMUSG00000026581
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 selpENSDARG00000042138Danio rerio
 SELLENSG00000188404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Selp / Q01102 / selectin, platelet / P16109* / selectin P*ENSMUSG0000002658045
Sele / selectin, endothelial cell / P16581* / selectin E*ENSMUSG0000002658242
F13b / Q07968 / Coagulation factor XIII B chain / P05160*ENSMUSG0000002636816
Zp3r / zona pellucida 3 receptorENSMUSG0000004255415
C4bp / P08607 / C4b-binding protein ENSMUSG0000002640514
Cfh / P06909 / Complement factor H / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H related 4* / complement factor H related 3*ENSMUSG0000002636513
Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002639913
Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*ENSMUSG0000001649312
Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002640112
Gm4788 / complement factor H-related protein C isoform 2 / CFH* / CFHR4* / CFHR3* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 3* / complement factor ...ENSMUSG0000007059412
Apoh / Q01339 / Beta-2-glycoprotein 1 / P02749* / apolipoprotein H*ENSMUSG0000000004911
Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*ENSMUSG000000570379
Cfhr2 / complement factor H-related 2 / CFH* / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 4* / complement factor H related 3*ENSMUSG000000338986


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR002396  Selectin superfamily
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR016348  L-selectin
 IPR018378  C-type lectin, conserved site
 IPR033991  Selectin, C-type lectin-like domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0033198 response to ATP IDA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0070492 oligosaccharide binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Selltm3Hyn/Selltm3Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Selltm3Hyn/Selltm3Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Selltm1Alb/Selltm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Selltm2Tft/Selltm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Selltm2.1Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001830 decreased activated T cell number "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Selltm1Flv/Sell+
Genetic Background: involves: C57BL/6 * NOD

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Timp3tm1Web/Timp3tm1Web
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Selltm1Pest/Sell+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002351 abnormal cervical lymph node morphology "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selltm2.1Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Selltm2Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic Background: B6.129S6-Mapk8ip3tm1Rjd

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Selltm2Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003627 abnormal lymphocyte rolling "anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Timp3tm1Web/Timp3tm1Web
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Flv/Sell+
Genetic Background: involves: C57BL/6 * NOD

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

Allelic Composition: Selltm2Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

Allelic Composition: Selltm2Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Selltm3Hyn/Selltm3Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Selltm4Hyn/Selltm4Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp3tm1Web/Timp3tm1Web
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo4tm1Kca/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Selltm2.1Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Selltm2Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Selltm3Tft/Selltm3Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: Sellm2Btlr/Sellm2Btlr
Genetic Background: C57BL/6J-Sellm2Btlr

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

Allelic Composition: Selltm2Tft/Selltm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Alb/Selltm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Seletm2Hyn/Seletm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Selltm3Hyn/Selltm3Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Selltm4Hyn/Selltm4Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm3Hyn/Selltm3Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009636 small popliteal lymph nodes "reduced size of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Sellm2Btlr/Sellm2Btlr
Genetic Background: C57BL/6J-Sellm2Btlr

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: 129S/SvEv

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Selltm1Pest/Selltm1Pest
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Selltm1Pest/Sell+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

Allelic Composition: Selltm2Tft/Selltm2.1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Selltm3Hyn/Selltm3Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Selltm4Hyn/Selltm4Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Seletm1Hyn/Seletm1Hyn,Selltm1Hyn/Selltm1Hyn,Selptm1Hyn/Selptm1Hyn
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

Allelic Composition: Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020310 Q61826 / Madcam1 / Mus musculus mucosal vascular addressin cell adhesion molecule 1 (Madcam1), transcript variant 2, mRNA. / Q13477* / mucosal vascular addressin cell adhesion molecule 1*  / complex / reaction
 ENSMUSG00000016494 Cd34 / Q64314 / Hematopoietic progenitor cell antigen CD34 / P28906* / CD34 molecule*  / complex / reaction






 

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