ENSDARG00000093411


Danio rerio
pyridoxalgad1atransferaseactivitydomainbindinggabasynthesisdecarboxylasemajorpyridoxal-phosphatesitecarboxylicacidmetabolicprocesscatalyticlyasecarboxy-lyasephosphatereleasereuptakedegradation

Features
Gene ID: ENSDARG00000093411
  
Biological name :gad1a
  
Synonyms : gad1a / glutamate decarboxylase 1a
  
Possible biological names infered from orthology : GAD1 / glutamate decarboxylase 1 / P48318 / Q99259
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 3621968
Gene end: 3653271
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000002225
Ensembl peptide - ENSDARP00000122377
swissprot - E7FDZ2
swissprot - F6NX32
ZFIN ID - ZDB-GENE-070912-472
Ensembl - ENSDARG00000093411
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GAD1ENSGALG00000034070Gallus gallus
 GAD1ENSG00000128683Homo sapiens
 Gad1ENSMUSG00000070880Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gad1b / glutamate decarboxylase 1b / GAD1* / Q99259* / P48318* / glutamate decarboxylase 1*ENSDARG0000002741986
gad2 / glutamate decarboxylase 2 / P48320* / Q05329* / glutamic acid decarboxylase 2*ENSDARG0000001553761
zgc:163121ENSDARG0000005537057
csad / cysteine sulfinic acid decarboxylase / Q9DBE0* / Q9Y600*ENSDARG0000002634843
hdc / histidine decarboxylase / P19113* / P23738*ENSDARG0000007545418
ddc / dopa decarboxylase / O88533* / P20711* / Aromatic-L-amino-acid decarboxylase *ENSDARG0000001649417


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR021115  Pyridoxal-phosphate binding site


Gene Ontology (GO)
cellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processorganic substance metabolic processcellular metabolic processcellular metabolic processsmall molecule metabolic processsmall molecule metabolic processorganic substance metabolic processorganic substance metabolic process
lyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activityion bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingdrug bindinglyase activitylyase activityion bindingion bindingorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindingcofactor bindingcofactor bindingsmall molecule bindismall molecule bindingdrug bindingdrug binding
TypeGO IDTermEv.Code
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
GABA synthesis
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000027419 gad1b / glutamate decarboxylase 1b / GAD1* / Q99259* / P48318* / glutamate decarboxylase 1*  / complex
 ENSDARG00000015537 gad2 / glutamate decarboxylase 2 / P48320* / Q05329* / glutamic acid decarboxylase 2*  / complex
 ENSDARG00000093411 gad1a / glutamate decarboxylase 1a / GAD1* / Q99259* / P48318* / glutamate decarboxylase 1*  / complex






 

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