ENSDARG00000098639


Danio rerio

Features
Gene ID: ENSDARG00000098639
  
Biological name :pycr1b
  
Synonyms : pycr1b / pyrroline-5-carboxylate reductase 1b
  
Possible biological names infered from orthology : AL117348.2 / P32322 / PYCR1 / PYCR2 / pyrroline-5-carboxylate reductase 1 / pyrroline-5-carboxylate reductase 2 / pyrroline-5-carboxylate reductase family, member 2 / Q922Q4 / Q922W5 / Q96C36
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 45286911
Gene end: 45298524
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131306
Ensembl peptide - ENSDARP00000147942
Ensembl peptide - ENSDARP00000142190
NCBI entrez gene - 100149838     See in Manteia.
RefSeq - NM_001320425
RefSeq - XM_021479538
RefSeq Peptide - NP_001307354
swissprot - F1RDD0
swissprot - A0A140LG13
swissprot - A0A0H2UKQ7
ZFIN ID - ZDB-GENE-050522-26
Ensembl - ENSDARG00000098639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PYCR1ENSGALG00000007300Gallus gallus
 AL117348.2ENSG00000255835Homo sapiens
 PYCR1ENSG00000183010Homo sapiens
 PYCR2ENSG00000143811Homo sapiens
 Pycr1ENSMUSG00000025140Mus musculus
 Pycr2ENSMUSG00000026520Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pycr1a / pyrroline-5-carboxylate reductase 1a / PYCR2* / PYCR1* / Q922W5* / P32322* / Q96C36* / Q922Q4* / AL117348.2* / pyrroline-5-carboxylate reductase 2* / pyrroline-5-carboxylate reduct...ENSDARG0000010225484
pycr3 / Q5SPD7 / pyrroline-5-carboxylate reductase 3 / Pycrl* / Q53H96* / Q9DCC4*ENSDARG0000001523636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000304  Pyrroline-5-carboxylate reductase
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR016040  NAD(P)-binding domain
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR029036  Pyrroline-5-carboxylate reductase, dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006561 proline biosynthetic process IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055129 L-proline biosynthetic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004735 pyrroline-5-carboxylate reductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain decreased size , abnormal
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 ZFA:0000100 cerebellum cerebellum hemorrhagic , abnormal
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 ZFA:0000105 epidermis epidermis atrophied , abnormal
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 ZFA:0000109 forebrain forebrain decreased size , abnormal
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 ZFA:0000128 midbrain midbrain decreased size , abnormal
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 ZFA:0000155 somite somite morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
whole organism decreased length , abnormal
whole organism apoptotic , abnormal
whole organism malformed , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk shortened , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region increased curvature , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000098639 pycr1b / pyrroline-5-carboxylate reductase 1b / PYCR2* / PYCR1* / Q922W5* / P32322* / Q96C36* / Q922Q4* / AL117348.2* / pyrroline-5-carboxylate reductase 2* / pyrroline-5-carboxylate reduct...  / complex
 ENSDARG00000102254 pycr1a / pyrroline-5-carboxylate reductase 1a / PYCR2* / PYCR1* / Q922W5* / P32322* / Q96C36* / Q922Q4* / AL117348.2* / pyrroline-5-carboxylate reductase 2* / pyrroline-5-carboxylate reduct...  / complex






 

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