ENSDARG00000104393


Danio rerio

Features
Gene ID: ENSDARG00000104393
  
Biological name :npr2
  
Synonyms : natriuretic peptide receptor 2 / npr2
  
Possible biological names infered from orthology : P20594 / Q6VVW5
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 54580962
Gene end: 54661956
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131437
Ensembl peptide - ENSDARP00000152476
swissprot - A0A0G2KGK2
ZFIN ID - ZDB-GENE-141030-2
Ensembl - ENSDARG00000104393
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPR2ENSGALG00000027630Gallus gallus
 NPR2ENSG00000159899Homo sapiens
 Npr2ENSMUSG00000028469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
npr1b / natriuretic peptide receptor 1b / NPR1* / P16066* / P18293* / natriuretic peptide receptor 1*ENSDARG0000001875058
npr1a / natriuretic peptide receptor 1a / NPR1* / P16066* / P18293* / natriuretic peptide receptor 1*ENSDARG0000003175158
si:dkey-37g12.1ENSDARG0000006026436
gucy2f / guanylate cyclase 2F, retinalENSDARG0000002550432
gucy2g / guanylate cyclase 2g / Q6TL19*ENSDARG0000007677632
gc2 / guanylyl cyclase 2 / GUCY2F* / P51841* / Q5SDA5* / Retinal guanylyl cyclase 2 * / guanylate cyclase 2F, retinal*ENSDARG0000001832931
gucy2d / guanylate cyclase 2D, retinal / Gucy2e* / P52785* / Q02846* / Guanylyl cyclase GC-E *ENSDARG0000002682030
si:ch73-139e5.4 / GUCY2C* / P25092* / Q3UWA6* / guanylate cyclase 2C* / Heat-stable enterotoxin receptor *ENSDARG0000005604529
gucy2c / guanylate cyclase 2C / P25092*ENSDARG0000001432026
gucy1b2 / guanylate cyclase 1, soluble, beta 2ENSDARG0000005659115
GUCY1A2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSDARG0000009318514
gucy1a1 / guanylate cyclase 1 soluble subunit alpha 1 / Q02108* / Q9ERL9* / guanylate cyclase 1, soluble, alpha 1*ENSDARG0000001378713
gucy1b1 / guanylate cyclase 1 soluble subunit beta 1 / O54865* / Q02153* / guanylate cyclase 1, soluble, beta 1*ENSDARG0000008679013
si:ch211-215j19.12ENSDARG0000010407212
si:dkey-239n17.6ENSDARG000000958486


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001170  Adenylyl cyclase class-4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007168 receptor guanylyl cyclase signaling pathway IBA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0016941 natriuretic peptide receptor activity IBA


Pathways (from Reactome)
Pathway description
Physiological factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000068126 nppc / natriuretic peptide C / P23582* / Q61839* / natriuretic peptide type C*  / complex / reaction






 

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