ENSDARG00000105116


Danio rerio

Features
Gene ID: ENSDARG00000105116
  
Biological name :p4hb
  
Synonyms : p4hb / prolyl 4-hydroxylase, beta polypeptide
  
Possible biological names infered from orthology : P07237 / P09103 / prolyl 4-hydroxylase subunit beta
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 18203464
Gene end: 18228358
  
Corresponding Affymetrix probe sets: NM_213364_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000138657
NCBI entrez gene - 406673     See in Manteia.
RefSeq - NM_213364
RefSeq Peptide - NP_998529
swissprot - A0A0R4ISX6
ZFIN ID - ZDB-GENE-080610-1
Ensembl - ENSDARG00000105116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P4HBENSGALG00000038290Gallus gallus
 P4HBENSG00000185624Homo sapiens
 P4hbENSMUSG00000025130Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdia2 / protein disulfide isomerase family A, member 2 / D3Z6P0* / Q13087* / Protein disulfide-isomerase A2 *ENSDARG0000001826346
zgc:136472 / PDILT* / Q9DAN1* / Q8N807* / protein disulfide isomerase like, testis expressed* / Protein disulfide-isomerase-like protein of the testis *ENSDARG0000005844535
zgc:77086ENSDARG0000001401531
pdia4 / protein disulfide isomerase family A, member 4 / P13667*ENSDARG0000001849131
zgc:100906ENSDARG0000003359930
pdia3 / protein disulfide isomerase family A, member 3 / P27773* / P30101* / Protein disulfide-isomerase A3 *ENSDARG0000010264029
erp44 / endoplasmic reticulum protein 44 / Q9BS26* / Q9D1Q6* / Endoplasmic reticulum resident protein 44 *ENSDARG0000001900817
tmx3a / thioredoxin related transmembrane protein 3a / TMX3* / Q8BXZ1* / Q96JJ7* / Protein disulfide-isomerase TMX3 * / thioredoxin related transmembrane protein 3*ENSDARG0000003889415
tmx3b / thioredoxin related transmembrane protein 3b / TMX3* / Q96JJ7* / thioredoxin related transmembrane protein 3*ENSDARG000000884667


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR005792  Protein disulphide isomerase
 IPR012336  Thioredoxin-like fold
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045454 cell redox homeostasis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes
Detoxification of Reactive Oxygen Species
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
VLDL assembly
Post-translational protein phosphorylation
Chylomicron assembly
Interleukin-12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008637 mttp / A0A0R4IVV0 / microsomal triglyceride transfer protein / P55157* / O08601* / Microsomal triglyceride transfer protein large subunit *  / complex
 ENSDARG00000010085 p4ha2 / procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 / O15460* / prolyl 4-hydroxylase subunit alpha 2*  / reaction / complex
 ENSDARG00000033537 p4ha1a / prolyl 4-hydroxylase, alpha polypeptide I a / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*  / reaction / complex
 ENSDARG00000071082 p4ha1b / prolyl 4-hydroxylase, alpha polypeptide I b / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*  / reaction / complex
 ENSDARG00000020007 col1a2 / collagen, type I, alpha 2 / Q01149* / P08123* / Collagen alpha-2(I) chain * / collagen type I alpha 2 chain*  / complex / reaction
 ENSDARG00000101535 col10a1b / collagen, type X, alpha 1b / Q03692* / COL10A1* / collagen type X alpha 1 chain*  / complex / reaction
 ENSDARG00000105116 p4hb / prolyl 4-hydroxylase, beta polypeptide / P07237* / P09103* / prolyl 4-hydroxylase subunit beta*  / complex / reaction






 

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