ENSG00000054796


Homo sapiens

Features
Gene ID: ENSG00000054796
  
Biological name :SPO11
  
Synonyms : Q9Y5K1 / SPO11 / SPO11, initiator of meiotic double stranded breaks
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.31
Gene start: 57329759
Gene end: 57343994
  
Corresponding Affymetrix probe sets: 222259_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360307
Ensembl peptide - ENSP00000413185
Ensembl peptide - ENSP00000431842
Ensembl peptide - ENSP00000316034
Ensembl peptide - ENSP00000360310
NCBI entrez gene - 23626     See in Manteia.
OMIM - 605114
RefSeq - XM_011528757
RefSeq - NM_012444
RefSeq - NM_198265
RefSeq - XM_005260379
RefSeq - XM_005260380
RefSeq - XM_005260381
RefSeq - XM_005260382
RefSeq - XM_011528756
RefSeq Peptide - NP_036576
RefSeq Peptide - NP_937998
swissprot - H0YCK9
swissprot - Q5TCH6
swissprot - Q5TCH7
swissprot - Q9Y5K1
Ensembl - ENSG00000054796
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spo11ENSDARG00000013837Danio rerio
 SPO11ENSGALG00000031768Gallus gallus
 Spo11ENSMUSG00000005883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002815  Spo11/DNA topoisomerase VI subunit A
 IPR004084  Meiosis-specific protein Spo11
 IPR013048  Meiotic recombination, Spo11
 IPR013049  Spo11/DNA topoisomerase VI, subunit A, N-terminal
 IPR034136  Topoisomerase 6 subunit A/Spo11, TOPRIM domain
 IPR036078  Spo11/DNA topoisomerase VI subunit A superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000706 meiotic DNA double-strand break processing IBA
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007130 synaptonemal complex assembly IEA
 biological_processGO:0007131 reciprocal meiotic recombination IEA
 biological_processGO:0007141 male meiosis I IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007292 female gamete generation TAS
 biological_processGO:0034502 protein localization to chromosome IEA
 biological_processGO:0042138 meiotic DNA double-strand break formation IBA
 biological_processGO:0045141 meiotic telomere clustering IEA
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:1990918 double-strand break repair involved in meiotic recombination IEA
 cellular_componentGO:0000228 nuclear chromosome IBA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0016889 endodeoxyribonuclease activity, producing 3"-phosphomonoesters IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000054796 SPO11 / Q9Y5K1 / SPO11, initiator of meiotic double stranded breaks  / complex






 

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