ENSMUSG00000005883


Mus musculus

Features
Gene ID: ENSMUSG00000005883
  
Biological name :Spo11
  
Synonyms : Meiotic recombination protein SPO11 / Q9WTK8 / Spo11
  
Possible biological names infered from orthology : Q9Y5K1 / SPO11, initiator of meiotic double stranded breaks
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 172977700
Gene end: 172993576
  
Corresponding Affymetrix probe sets: 10479010 (MoGene1.0st)   1417021_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059056
Ensembl peptide - ENSMUSP00000104753
Ensembl peptide - ENSMUSP00000104754
NCBI entrez gene - 26972     See in Manteia.
MGI - MGI:1349669
RefSeq - XM_017318894
RefSeq - NM_001083959
RefSeq - NM_001083960
RefSeq - NM_001305434
RefSeq - NM_012046
RefSeq - XM_006499617
RefSeq - XM_006499618
RefSeq - XM_006499619
RefSeq - XM_006499620
RefSeq - XM_006499622
RefSeq Peptide - NP_001077429
RefSeq Peptide - NP_001292363
RefSeq Peptide - NP_036176
RefSeq Peptide - NP_001077428
swissprot - Q9WTK8
Ensembl - ENSMUSG00000005883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spo11ENSDARG00000013837Danio rerio
 SPO11ENSGALG00000031768Gallus gallus
 SPO11ENSG00000054796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002815  Spo11/DNA topoisomerase VI subunit A
 IPR004084  Meiosis-specific protein Spo11
 IPR013048  Meiotic recombination, Spo11
 IPR013049  Spo11/DNA topoisomerase VI, subunit A, N-terminal
 IPR034136  Topoisomerase 6 subunit A/Spo11, TOPRIM domain
 IPR036078  Spo11/DNA topoisomerase VI subunit A superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000706 meiotic DNA double-strand break processing IBA
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IEA
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007131 reciprocal meiotic recombination IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0034502 protein localization to chromosome IMP
 biological_processGO:0042138 meiotic DNA double-strand break formation IBA
 biological_processGO:0045141 meiotic telomere clustering IMP
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:1990918 double-strand break repair involved in meiotic recombination IGI
 cellular_componentGO:0000228 nuclear chromosome IBA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0016888 endodeoxyribonuclease activity, producing 5"-phosphomonoesters TAS
 molecular_functionGO:0016889 endodeoxyribonuclease activity, producing 3"-phosphomonoesters IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
Genetic Background: involves: C57BL/6

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
Genetic Background: involves: C57BL/6

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hormad2tm1Kura/Hormad2+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn,Syce2Gt(FHCRC-GT-S8-7E1)Sor/Syce2Gt(FHCRC-GT-S8-7E1)Sor
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1Roua/Ireb2tm1Roua
Genetic Background: B6.Cg-Ireb2tm1Roua

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hormad2tm1Atot/Hormad2tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm3Rdco/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Rad50tm4.1Jpt/Rad50+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
Genetic Background: involves: C57BL/6

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

Allelic Composition: Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hormad2tm1Kura/Hormad2+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Maeltm1Bort/Maeltm1Bort,Spo11tm1Rdco/Spo11tm1Rdco
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Spo11tm2.1Rdco/Spo11tm2.1Rdco
Genetic Background: B6.129S6-Spo11tm2.1Rdco

Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rec8mei8/Rec8mei8,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad2tm1Kura/Hormad2+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tyrskc35/Tyrskc35
Genetic Background: Not Specified

Allelic Composition: Spo11tm1Rdco/Spo11tm1Rdco
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Spo11tm2.1Rdco/Spo11tm2.1Rdco
Genetic Background: B6.129S6-Spo11tm2.1Rdco

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

Allelic Composition: Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hormad1tm1Kura/Hormad1tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6JOlaHsd

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hormad1tm1Atot/Hormad1tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad1tm1.2Atot/Hormad1tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

Allelic Composition: Rec8mei8/Rec8mei8,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Mcmdc2tm3b(EUCOMM)Hmgu/Mcmdc2tm3b(EUCOMM)Hmgu,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6N * CD-1

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
Genetic Background: involves: C57BL/6

Allelic Composition: Psmc3iptm1Rdco/Psmc3iptm1Rdco,Spo11tm1.1Gvpc/Spo11tm1.1Gvpc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

Allelic Composition: Mcmdc2tm3b(EUCOMM)Hmgu/Mcmdc2tm3b(EUCOMM)Hmgu,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6N * CD-1

 MP:0011751 abnormal X-Y chromosome synapsis during male meiosis "an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction" [MGI:llw2]
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Allelic Composition: Spo11tm1Bdm/Spo11tm1Bdm
Genetic Background: involves: 129

Allelic Composition: Spo11tm1.1Gvpc/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005883 Spo11 / Q9WTK8 / Meiotic recombination protein SPO11 / Q9Y5K1* / SPO11, initiator of meiotic double stranded breaks*  / complex






 

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