ENSG00000061918


Homo sapiens

Features
Gene ID: ENSG00000061918
  
Biological name :GUCY1B1
  
Synonyms : guanylate cyclase 1 soluble subunit beta 1 / GUCY1B1 / Q02153
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.1
Gene start: 155758992
Gene end: 155807591
  
Corresponding Affymetrix probe sets: 203817_at (Human Genome U133 Plus 2.0 Array)   211555_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425065
Ensembl peptide - ENSP00000422313
Ensembl peptide - ENSP00000426319
Ensembl peptide - ENSP00000427226
Ensembl peptide - ENSP00000426786
Ensembl peptide - ENSP00000264424
Ensembl peptide - ENSP00000420842
NCBI entrez gene - 2983     See in Manteia.
OMIM - 139397
RefSeq - XM_017008133
RefSeq - NM_000857
RefSeq - NM_001291951
RefSeq - NM_001291952
RefSeq - NM_001291953
RefSeq - NM_001291954
RefSeq - NM_001291955
RefSeq - XM_011531901
RefSeq - XM_017008130
RefSeq - XM_017008131
RefSeq - XM_017008132
RefSeq Peptide - NP_001278880
RefSeq Peptide - NP_001278882
RefSeq Peptide - NP_001278883
RefSeq Peptide - NP_001278884
RefSeq Peptide - NP_000848
RefSeq Peptide - NP_001278881
swissprot - D6RC99
swissprot - E9PCN2
swissprot - Q02153
swissprot - B7Z685
Ensembl - ENSG00000061918
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gucy1b1ENSDARG00000086790Danio rerio
 GUCY1B1ENSGALG00000009361Gallus gallus
 O54865ENSMUSG00000028005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P33402 / GUCY1A2 / guanylate cyclase 1 soluble subunit alpha 2ENSG0000015240234
Q02108 / GUCY1A1 / guanylate cyclase 1 soluble subunit alpha 1ENSG0000016411632
GUCY2F / P51841 / guanylate cyclase 2F, retinalENSG0000010189023
NPR1 / P16066 / natriuretic peptide receptor 1ENSG0000016941823
GUCY2D / Q02846 / guanylate cyclase 2D, retinalENSG0000013251822
NPR2 / P20594 / natriuretic peptide receptor 2ENSG0000015989922
GUCY2C / P25092 / guanylate cyclase 2CENSG0000007001920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR011644  Heme NO-binding
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR024096  NO signalling/Golgi transport ligand-binding domain superfamily
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction TAS
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0019934 cGMP-mediated signaling IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038060 nitric oxide-cGMP-mediated signaling pathway ISS
 biological_processGO:0071732 cellular response to nitric oxide ISS
 biological_processGO:0099555 trans-synaptic signaling by nitric oxide, modulating synaptic transmission IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IDA
 cellular_componentGO:0048786 presynaptic active zone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0004383 guanylate cyclase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0043167 ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047805 cytidylate cyclase activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
Nitric oxide stimulates guanylate cyclase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152402 P33402 / GUCY1A2 / guanylate cyclase 1 soluble subunit alpha 2  / complex
 ENSG00000164116 Q02108 / GUCY1A1 / guanylate cyclase 1 soluble subunit alpha 1  / complex






 

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