ENSG00000152402


Homo sapiens

Features
Gene ID: ENSG00000152402
  
Biological name :GUCY1A2
  
Synonyms : guanylate cyclase 1 soluble subunit alpha 2 / GUCY1A2 / P33402
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.3
Gene start: 106674012
Gene end: 107018524
  
Corresponding Affymetrix probe sets: 206927_s_at (Human Genome U133 Plus 2.0 Array)   228731_at (Human Genome U133 Plus 2.0 Array)   228732_at (Human Genome U133 Plus 2.0 Array)   230665_at (Human Genome U133 Plus 2.0 Array)   236335_at (Human Genome U133 Plus 2.0 Array)   242342_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282249
Ensembl peptide - ENSP00000344874
Ensembl peptide - ENSP00000431245
NCBI entrez gene - 2977     See in Manteia.
OMIM - 601244
RefSeq - NM_000855
RefSeq - NM_001256424
RefSeq Peptide - NP_000846
RefSeq Peptide - NP_001243353
swissprot - P33402
Ensembl - ENSG00000152402
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GUCY1A2ENSDARG00000093185Danio rerio
 GUCY1A2ENSGALG00000017173Gallus gallus
 Gucy1a2ENSMUSG00000041624Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q02108 / GUCY1A1 / guanylate cyclase 1 soluble subunit alpha 1ENSG0000016411645
Q02153 / GUCY1B1 / guanylate cyclase 1 soluble subunit beta 1ENSG0000006191828
GUCY2F / P51841 / guanylate cyclase 2F, retinalENSG0000010189023
GUCY2D / Q02846 / guanylate cyclase 2D, retinalENSG0000013251822
NPR1 / P16066 / natriuretic peptide receptor 1ENSG0000016941822
NPR2 / P20594 / natriuretic peptide receptor 2ENSG0000015989921
GUCY2C / P25092 / guanylate cyclase 2CENSG0000007001920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR011644  Heme NO-binding
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR024096  NO signalling/Golgi transport ligand-binding domain superfamily
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0020037 heme binding IEA


Pathways (from Reactome)
Pathway description
Nitric oxide stimulates guanylate cyclase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000061918 Q02153 / GUCY1B1 / guanylate cyclase 1 soluble subunit beta 1  / complex






 

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