ENSG00000064687
Homo sapiens regulation ABCA7 atpase membrane activity abc transporter efflux phospholipid protein cell atp-binding cassette phagocytosis memory cholesterol apolipoprotein transmembrane erk amyloid-beta golgi endosome binding impairment transporter-like aaa domain aaa-type core conserved site
Features See expression report in BioGPS See gene description in Wikigenes See gene description in GeneCards See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) ABCA1 / O95477 / ATP binding cassette subfamily A member 1 ENSG00000165029 52 ABCA4 / P78363 / ATP binding cassette subfamily A member 4 ENSG00000198691 46 ABCA2 / Q9BZC7 / ATP binding cassette subfamily A member 2 ENSG00000107331 37 ABCA13 / Q86UQ4 / ATP binding cassette subfamily A member 13 ENSG00000179869 32 ABCA12 / Q86UK0 / ATP binding cassette subfamily A member 12 ENSG00000144452 31 ABCA3 / Q99758 / ATP binding cassette subfamily A member 3 ENSG00000167972 28 ABCA8 / O94911 / ATP binding cassette subfamily A member 8 ENSG00000141338 20 ABCA9 / Q8IUA7 / ATP binding cassette subfamily A member 9 ENSG00000154258 20 ABCA6 / Q8N139 / ATP binding cassette subfamily A member 6 ENSG00000154262 19 ABCA5 / Q8WWZ7 / ATP binding cassette subfamily A member 5 ENSG00000154265 19 ABCA10 / Q8WWZ4 / ATP binding cassette subfamily A member 10 ENSG00000154263 18
Protein motifs (from Interpro )Gene Ontology (GO ) establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishment of localization system process macromolecule localization nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process cellular component organization cellular component biogenesis cellular localization cell communication cellular response to stimulus biosynthetic process regulation of biological quality amyloid-beta clearance establishestablishment of localization system prsystem process macromolemacromolecule localization nitrogen nitrogen compound metabolic process cellular cellular metabolic process primary mprimary metabolic process organic sorganic substance metabolic process cellular cellular component organization cellular cellular component biogenesis cellular cellular localization cell commcell communication cellular cellular response to stimulus biosynthebiosynthetic process regulatioregulation of biological quality amyloid-bamyloid-beta clearance organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclic compound binding heterocyclic compound binding small molecule binding ion binding carbohydrate derivative binding drug binding hydrolase activity apolipoprotein receptor activity signaling receptor activity transmembrane transporter activity lipid transporter activity organic cyclorganic cyclic compound binding heterocyclicheterocyclic compound binding small molecusmall molecule binding ion bindingion binding carbohydratecarbohydrate derivative binding drug bindingdrug binding hydrolase achydrolase activity apolipoproteapolipoprotein receptor activity signaling resignaling receptor activity transmembrantransmembrane transporter activity lipid transplipid transporter activity cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cell membrane organelle cell junction protein-containing complex cellcell membranemembrane organelleorganelle cell junctioncell junction protein-containing complexprotein-containing complex
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyes Neurological abnormality Abnormality of musculature Abnormality of the eyesAbnormality of the eyes Neurological abnormalityNeurological abnormality Abnormality of musculatureAbnormality of musculature HP:0000504 Abnormality of vision "Abnormality of eyesight (visual perception)." [HPO:curators]
Show HP:0000657 Oculomotor apraxia
Show HP:0000713 Agitation
Show HP:0000734 Disinhibition
Show HP:0000738 Hallucinations
Show HP:0001249 Mental retardation
Show HP:0001250 Seizures "Seizures are an intermittent `abnormality of the central nervous system` (FMA:HP:0002011) due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements." [HPO:probinson]
Show HP:0001251 Ataxia "Ataxia is a nonspecific neurological sign and symptom consisting of gross lack of coordination of muscle movements. Ataxia is caused by dysfunction of one or more parts of the nervous system including the cerebellum, the sensory nervous system, the vestibular system, or the cerebral cortex." [HPO:curators]
Show HP:0001276 Hypertonia
Show HP:0001289 Confusion "Lack of clarity and coherence of thought, perception, understanding, or action." [HPO:curators]
Show HP:0001300 Parkinsonism
Show HP:0001336 Myoclonus "Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements." [HPO:curators]
Show HP:0002120 Cerebral cortical atrophy
Show HP:0002185 Neurofibrillary tangles
Show HP:0002354 Memory impairment
Show HP:0002381 Aphasia
Show HP:0002463 Language impairment
Show HP:0003791 Deposits immunoreactive to beta-amyloid protein
Show HP:0010525 Finger agnosia "An inability or difficulty differentiating among the fingers of either hand as well as the hands of others." [HPO:curators]
Show HP:0010526 Dysgraphia "A writing disability in the absence of motor or sensory deficits of the upper extremities, resulting in an impairment in the ability to write regardless of the ability to read and not due to intellectual impairment." [HPO:curators]
Show HP:0012433 Abnormal social behavior "An abnormality of actions or reactions of a person taking place during interactions with others." [HPO:probinson]
Show HP:0030219 Semantic dementia "A progressive loss of the ability to remember the meaning of words, faces and objects." [ICM:PCaroppo, pmid:24966676]
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Interacting proteins (from Reactome )
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