ENSG00000065989


Homo sapiens

Features
Gene ID: ENSG00000065989
  
Biological name :PDE4A
  
Synonyms : P27815 / PDE4A / phosphodiesterase 4A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 10416773
Gene end: 10469631
  
Corresponding Affymetrix probe sets: 204735_at (Human Genome U133 Plus 2.0 Array)   211447_s_at (Human Genome U133 Plus 2.0 Array)   211591_s_at (Human Genome U133 Plus 2.0 Array)   211901_s_at (Human Genome U133 Plus 2.0 Array)   242435_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468507
Ensembl peptide - ENSP00000465792
Ensembl peptide - ENSP00000467137
Ensembl peptide - ENSP00000293683
Ensembl peptide - ENSP00000341007
Ensembl peptide - ENSP00000370078
Ensembl peptide - ENSP00000394754
NCBI entrez gene - 5141     See in Manteia.
OMIM - 600126
RefSeq - XM_017026865
RefSeq - NM_001111307
RefSeq - NM_001111308
RefSeq - NM_001111309
RefSeq - NM_001243121
RefSeq - NM_006202
RefSeq - XM_005259933
RefSeq - XM_011528054
RefSeq - XM_011528055
RefSeq Peptide - NP_001230050
RefSeq Peptide - NP_001104777
RefSeq Peptide - NP_001104778
RefSeq Peptide - NP_006193
RefSeq Peptide - NP_001104779
swissprot - P27815
swissprot - K7ENX7
swissprot - K7EKV1
Ensembl - ENSG00000065989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4aENSDARG00000032344Danio rerio
 Pde4aENSMUSG00000032177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344857
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458855
PDE4C / Q08493 / phosphodiesterase 4CENSG0000010565054
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG0000028518854
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467822
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323120
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341719
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525218
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336018
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476218
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526817
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140816


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IGI
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007608 sensory perception of smell IEA
 biological_processGO:0010738 regulation of protein kinase A signaling IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0043949 regulation of cAMP-mediated signaling IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IGI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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