ENSMUSG00000032177


Mus musculus

Features
Gene ID: ENSMUSG00000032177
  
Biological name :Pde4a
  
Synonyms : O89084 / Pde4a / phosphodiesterase 4A, cAMP specific
  
Possible biological names infered from orthology : P27815 / phosphodiesterase 4A
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 21165714
Gene end: 21213248
  
Corresponding Affymetrix probe sets: 10583551 (MoGene1.0st)   1421535_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003395
Ensembl peptide - ENSMUSP00000037025
Ensembl peptide - ENSMUSP00000111118
NCBI entrez gene - 18577     See in Manteia.
MGI - MGI:99558
RefSeq - XM_017313211
RefSeq - NM_001310750
RefSeq - NM_019798
RefSeq - NM_183408
RefSeq - XM_006510091
RefSeq - XM_006510093
RefSeq Peptide - NP_899668
RefSeq Peptide - NP_001297679
RefSeq Peptide - NP_062772
swissprot - O89084
swissprot - B2RTL2
Ensembl - ENSMUSG00000032177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4aENSDARG00000032344Danio rerio
 PDE4AENSG00000065989Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde4d / Q01063 / cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q08499* / phosphodiesterase 4D*ENSMUSG0000002169957
Pde4b / phosphodiesterase 4B, cAMP specific / Q07343* / phosphodiesterase 4B*ENSMUSG0000002852557
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184250
Pde1c / Q64338 / phosphodiesterase 1C / Q14123*ENSMUSG0000000434721
Pde8b / E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / O95263* / AC022414.1* / phosphodiesterase 8B* / high affinity cAMP-specific and IBMX-ins...ENSMUSG0000002168420
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558419
Pde1a / phosphodiesterase 1A, calmodulin-dependent / P54750* / phosphodiesterase 1A*ENSMUSG0000005917319
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999018
Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*ENSMUSG0000002248918
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909418


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007608 sensory perception of smell IGI
 biological_processGO:0010738 regulation of protein kinase A signaling IMP
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0043949 regulation of cAMP-mediated signaling IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IDA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0009562 abnormal odor adaptation "altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde1ctm1.1Hazh/Pde1ctm1.1Hazh,Pde4atm1.1Hazh/Pde4atm1.1Hazh
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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