ENSMUSG00000004347


Mus musculus

Features
Gene ID: ENSMUSG00000004347
  
Biological name :Pde1c
  
Synonyms : Pde1c / phosphodiesterase 1C / Q64338
  
Possible biological names infered from orthology : Q14123
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 56069804
Gene end: 56569103
  
Corresponding Affymetrix probe sets: 10544941 (MoGene1.0st)   1426036_a_at (Mouse Genome 430 2.0 Array)   1429643_a_at (Mouse Genome 430 2.0 Array)   1436251_at (Mouse Genome 430 2.0 Array)   1440374_at (Mouse Genome 430 2.0 Array)   1444067_at (Mouse Genome 430 2.0 Array)   1444386_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133170
Ensembl peptide - ENSMUSP00000131892
Ensembl peptide - ENSMUSP00000145419
Ensembl peptide - ENSMUSP00000145508
Ensembl peptide - ENSMUSP00000046601
Ensembl peptide - ENSMUSP00000109966
Ensembl peptide - ENSMUSP00000128364
Ensembl peptide - ENSMUSP00000129185
Ensembl peptide - ENSMUSP00000130139
Ensembl peptide - ENSMUSP00000131350
NCBI entrez gene - 18575     See in Manteia.
MGI - MGI:108413
RefSeq - XM_017321454
RefSeq - NM_001025568
RefSeq - NM_001159952
RefSeq - NM_001159953
RefSeq - NM_001159955
RefSeq - NM_001159956
RefSeq - NM_001159957
RefSeq - NM_001159960
RefSeq - NM_011054
RefSeq - XM_006505730
RefSeq - XM_006505732
RefSeq - XM_006505733
RefSeq - XM_006505734
RefSeq - XM_006505735
RefSeq - XM_011241250
RefSeq - XM_011241251
RefSeq - XM_017321453
RefSeq Peptide - NP_001342404
RefSeq Peptide - NP_001020739
RefSeq Peptide - NP_001153424
RefSeq Peptide - NP_001153425
RefSeq Peptide - NP_001153427
RefSeq Peptide - NP_001153428
RefSeq Peptide - NP_001153429
RefSeq Peptide - NP_035184
RefSeq Peptide - NP_001153432
swissprot - Q9D5W0
swissprot - A0A0N4SWG4
swissprot - Q5D0E7
swissprot - Q64338
swissprot - Q8CDV2
swissprot - E9Q7V6
swissprot - A0A0N4SW87
Ensembl - ENSMUSG00000004347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01067973.1ENSDARG00000090398Danio rerio
 PDE1CENSGALG00000039935Gallus gallus
 PDE1CENSG00000154678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde1a / phosphodiesterase 1A, calmodulin-dependent / P54750* / phosphodiesterase 1A*ENSMUSG0000005917352
Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*ENSMUSG0000002248945
Pde4a / O89084 / phosphodiesterase 4A, cAMP specific / P27815* / phosphodiesterase 4A*ENSMUSG0000003217725
Pde4d / Q01063 / cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q08499* / phosphodiesterase 4D*ENSMUSG0000002169924
Pde4b / phosphodiesterase 4B, cAMP specific / Q07343* / phosphodiesterase 4B*ENSMUSG0000002852523
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184222
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999016
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558416
Pde8b / E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / O95263* / AC022414.1* / phosphodiesterase 8B* / high affinity cAMP-specific and IBMX-ins...ENSMUSG0000002168415
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909415


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0051592 response to calcium ion ISO
 cellular_componentGO:0005929 cilium IDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity ISO
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048101 calcium- and calmodulin-regulated 3",5"-cyclic-GMP phosphodiesterase activity ISO


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Pde1ctm1.1Hazh/Pde1ctm1.1Hazh,Pde4atm1.1Hazh/Pde4atm1.1Hazh
Genetic Background: involves: 129S6/SvEvTac

 MP:0009562 abnormal odor adaptation "altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Pde1ctm1.1Hazh/Pde1ctm1.1Hazh,Pde4atm1.1Hazh/Pde4atm1.1Hazh
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004347 Pde1c / Q64338 / phosphodiesterase 1C / Q14123*  / complex






 

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