ENSMUSG00000059173


Mus musculus

Features
Gene ID: ENSMUSG00000059173
  
Biological name :Pde1a
  
Synonyms : Pde1a / phosphodiesterase 1A, calmodulin-dependent
  
Possible biological names infered from orthology : P54750 / phosphodiesterase 1A
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 79834453
Gene end: 80129458
  
Corresponding Affymetrix probe sets: 10484283 (MoGene1.0st)   1431625_at (Mouse Genome 430 2.0 Array)   1449298_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139327
Ensembl peptide - ENSMUSP00000099715
Ensembl peptide - ENSMUSP00000120188
Ensembl peptide - ENSMUSP00000088260
Ensembl peptide - ENSMUSP00000099711
Ensembl peptide - ENSMUSP00000099712
Ensembl peptide - ENSMUSP00000099713
Ensembl peptide - ENSMUSP00000099714
NCBI entrez gene - 18573     See in Manteia.
MGI - MGI:1201792
RefSeq - XM_011239356
RefSeq - NM_001009978
RefSeq - NM_001009979
RefSeq - NM_001159582
RefSeq - NM_001355140
RefSeq - NM_001355141
RefSeq - NM_001355142
RefSeq - NM_001355144
RefSeq - NM_016744
RefSeq - XM_006498919
RefSeq - XM_006498920
RefSeq - XM_006498921
RefSeq - XM_006498923
RefSeq Peptide - NP_001342069
RefSeq Peptide - NP_001342073
RefSeq Peptide - NP_058024
RefSeq Peptide - NP_001009978
RefSeq Peptide - NP_001009979
RefSeq Peptide - NP_001153054
RefSeq Peptide - NP_001342070
RefSeq Peptide - NP_001342071
swissprot - F6X0V1
swissprot - Q5I7S8
swissprot - Q8BRR9
swissprot - Q9JLL9
swissprot - A2ASF9
Ensembl - ENSMUSG00000059173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde1aENSDARG00000060875Danio rerio
 PDE1AENSGALG00000008885Gallus gallus
 PDE1AENSG00000115252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde1c / Q64338 / phosphodiesterase 1C / Q14123*ENSMUSG0000000434767
Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*ENSMUSG0000002248956
Pde4d / Q01063 / cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q08499* / phosphodiesterase 4D*ENSMUSG0000002169929
Pde4b / phosphodiesterase 4B, cAMP specific / Q07343* / phosphodiesterase 4B*ENSMUSG0000002852529
Pde4a / O89084 / phosphodiesterase 4A, cAMP specific / P27815* / phosphodiesterase 4A*ENSMUSG0000003217729
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184228
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558422
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999021
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909421
Pde8b / E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / O95263* / AC022414.1* / phosphodiesterase 8B* / high affinity cAMP-specific and IBMX-ins...ENSMUSG0000002168420


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0046069 cGMP catabolic process IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048101 calcium- and calmodulin-regulated 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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