ENSDARG00000060875


Danio rerio

Features
Gene ID: ENSDARG00000060875
  
Biological name :pde1a
  
Synonyms : pde1a / phosphodiesterase 1A, calmodulin-dependent
  
Possible biological names infered from orthology : P54750 / phosphodiesterase 1A
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 44498182
Gene end: 44642108
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080637
Ensembl peptide - ENSDARP00000117709
Ensembl peptide - ENSDARP00000155389
NCBI entrez gene - 564465     See in Manteia.
swissprot - E7F6Z8
swissprot - E9QDS2
ZFIN ID - ZDB-GENE-090831-2
Ensembl - ENSDARG00000060875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDE1AENSGALG00000008885Gallus gallus
 PDE1AENSG00000115252Homo sapiens
 Pde1aENSMUSG00000059173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CABZ01067973.1 / PDE1C* / Q14123* / phosphodiesterase 1C*ENSDARG0000009039860
pde4ca / phosphodiesterase 4C, cAMP-specific a / PDE4C* / Q3UEI1* / Q08493* / AC008397.2* / phosphodiesterase 4C* / cAMP-specific 3,5-cyclic phosphodiesterase 4C *ENSDARG0000001322126
pde4a / phosphodiesterase 4A, cAMP-specific / O89084* / P27815* / phosphodiesterase 4A*ENSDARG0000003234426
pde4d / phosphodiesterase 4D, cAMP-specific / Q01063* / Q08499* / phosphodiesterase 4D* / cAMP-specific 3,5-cyclic phosphodiesterase 4D *ENSDARG0000003276125
pde4ba / phosphodiesterase 4B, cAMP-specific a / PDE4B* / Q07343* / phosphodiesterase 4B* / phosphodiesterase 4B, cAMP specific*ENSDARG0000003286825
pde4cb / phosphodiesterase 4C, cAMP-specific b / PDE4C* / Q3UEI1* / Q08493* / AC008397.2* / phosphodiesterase 4C* / cAMP-specific 3,5-cyclic phosphodiesterase 4C *ENSDARG0000000241124
pde4bb / phosphodiesterase 4B, cAMP-specific b / PDE4B* / Q07343* / phosphodiesterase 4B* / phosphodiesterase 4B, cAMP specific*ENSDARG0000007423324
pde7a / phosphodiesterase 7A / P70453* / Q13946* / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A *ENSDARG0000004530520
pde8b / phosphodiesterase 8B / O95263* / AC022414.1* / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 *ENSDARG0000006370620
pde8a / phosphodiesterase 8A / O60658*ENSDARG0000008794115


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0048793 pronephros development IMP
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
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 ZFA:0001115 trunk trunk increased curvature , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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