ENSG00000123360


Homo sapiens

Features
Gene ID: ENSG00000123360
  
Biological name :PDE1B
  
Synonyms : PDE1B / phosphodiesterase 1B / Q01064
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.2
Gene start: 54549350
Gene end: 54579239
  
Corresponding Affymetrix probe sets: 206444_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478185
Ensembl peptide - ENSP00000243052
Ensembl peptide - ENSP00000442559
Ensembl peptide - ENSP00000447354
Ensembl peptide - ENSP00000448519
NCBI entrez gene - 5153     See in Manteia.
OMIM - 171891
RefSeq - XM_017019433
RefSeq - NM_000924
RefSeq - NM_001165975
RefSeq - NM_001288768
RefSeq - NM_001288769
RefSeq - NM_001315534
RefSeq - NM_001315535
RefSeq - XM_011538456
RefSeq - XM_017019432
RefSeq Peptide - NP_001275697
RefSeq Peptide - NP_001275698
RefSeq Peptide - NP_001302463
RefSeq Peptide - NP_001302464
RefSeq Peptide - NP_001159447
RefSeq Peptide - NP_000915
swissprot - Q01064
swissprot - B4DK72
swissprot - A0A087WTW8
swissprot - F8VZK3
swissprot - A0A024RB59
Ensembl - ENSG00000123360
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Pde1bENSMUSG00000022489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467859
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525257
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598930
PDE4C / Q08493 / phosphodiesterase 4CENSG0000010565029
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344829
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458829
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG0000028518829
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341724
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323121
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476221
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140820
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526820


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006198 cAMP catabolic process IDA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0030224 monocyte differentiation IEP
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IDA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042428 serotonin metabolic process IEA
 biological_processGO:0046069 cGMP catabolic process IDA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity TAS
 molecular_functionGO:0048101 calcium- and calmodulin-regulated 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123360 PDE1B / Q01064 / phosphodiesterase 1B  / complex






 

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