ENSG00000078900


Homo sapiens
transcriptionTP73regulationbindingpdnaresponsecellproteinapoptoticdomainfactorrnapolymeraseiiactivityprocessdamagetpregulatesdna-bindingclassmediatorcycledifferentiationsequence-specificsuperfamilydna-templatedsignalingpathwayinvolved

Features
Gene ID: ENSG00000078900
  
Biological name :TP73
  
Synonyms : O15350 / TP73 / tumor protein p73
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.32
Gene start: 3652520
Gene end: 3736201
  
Corresponding Affymetrix probe sets: 1554379_a_at (Human Genome U133 Plus 2.0 Array)   220804_s_at (Human Genome U133 Plus 2.0 Array)   232546_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474322
Ensembl peptide - ENSP00000367545
Ensembl peptide - ENSP00000474626
Ensembl peptide - ENSP00000475143
Ensembl peptide - ENSP00000340740
Ensembl peptide - ENSP00000346423
Ensembl peptide - ENSP00000350366
Ensembl peptide - ENSP00000367529
Ensembl peptide - ENSP00000367534
Ensembl peptide - ENSP00000367537
Ensembl peptide - ENSP00000367539
NCBI entrez gene - 7161     See in Manteia.
OMIM - 601990
RefSeq - NM_001204192
RefSeq - NM_001126240
RefSeq - NM_001126241
RefSeq - NM_001126242
RefSeq - NM_001204184
RefSeq - NM_001204185
RefSeq - NM_001204186
RefSeq - NM_001204187
RefSeq - NM_001204188
RefSeq - NM_001204189
RefSeq - NM_001204190
RefSeq - NM_001204191
RefSeq - NM_005427
RefSeq Peptide - NP_005418
RefSeq Peptide - NP_001191119
RefSeq Peptide - NP_001191120
RefSeq Peptide - NP_001191121
RefSeq Peptide - NP_001119712
RefSeq Peptide - NP_001119713
RefSeq Peptide - NP_001119714
RefSeq Peptide - NP_001191113
RefSeq Peptide - NP_001191114
RefSeq Peptide - NP_001191115
RefSeq Peptide - NP_001191116
RefSeq Peptide - NP_001191117
RefSeq Peptide - NP_001191118
swissprot - O15350
swissprot - A0A0C4DFW9
swissprot - A0A024R4C3
Ensembl - ENSG00000078900
  
Related genetic diseases (OMIM): 601990 - ?Neuroblastoma

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp73ENSDARG00000017953Danio rerio
 TP73ENSGALG00000001006Gallus gallus
 Trp73ENSMUSG00000029026Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TP63 / Q9H3D4 / tumor protein p63ENSG0000007328253
TP53 / P04637 / tumor protein p53ENSG0000014151024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032646  Tumour protein p73
 IPR036674  p53-like tetramerisation domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentresponse to stresscell deathcell cycleresponse to abiotic stimulusresponse to chemicalinterspecies interaction between organismscellular developmental processcellular component organizationcellular component biogenesismuscle cell proliferationdevelopmental growthmacromolecule localizationestablishment of localizationregulation of biological qualitycellular localizationnitronitrogen compound metabolic processbiosybiosynthetic processcellucellular metabolic processprimaprimary metabolic processorganorganic substance metabolic processcell cell communicationregulregulation of molecular functioncellucellular response to stimulusanatoanatomical structure developmentresporesponse to stresscell cell deathcell cell cycleresporesponse to abiotic stimulusresporesponse to chemicalinterinterspecies interaction between organismscellucellular developmental processcellucellular component organizationcellucellular component biogenesismusclmuscle cell proliferationdeveldevelopmental growthmacromacromolecule localizationestabestablishment of localizationregulregulation of biological qualitycellucellular localization
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingchromatin bindingion bindingorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingDNA-binding transcriptiDNA-binding transcription factor activityprotein bindingprotein bindingchromatin bindingchromatin bindingion bindingion binding
cellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellorganellemembrane-enclosed lumenprotein-containing complexcell junctioncellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complexcell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006298 mismatch repair TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage TAS
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010332 response to gamma radiation IBA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IBA
 biological_processGO:0034644 cellular response to UV IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088808 Q96KQ4 / PPP1R13B / protein phosphatase 1 regulatory subunit 13B  / complex / reaction
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / complex / reaction
 ENSG00000143514 Q13625 / TP53BP2 / tumor protein p53 binding protein 2  / complex / reaction
 ENSG00000078900 TP73 / O15350 / tumor protein p73  / complex
 ENSG00000104881 Q8WUF5 / PPP1R13L / protein phosphatase 1 regulatory subunit 13 like  / complex / reaction






 

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