ENSG00000091542


Homo sapiens

Features
Gene ID: ENSG00000091542
  
Biological name :ALKBH5
  
Synonyms : ALKBH5 / alkB homolog 5, RNA demethylase / Q6P6C2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p11.2
Gene start: 18183078
Gene end: 18209954
  
Corresponding Affymetrix probe sets: 1553101_a_at (Human Genome U133 Plus 2.0 Array)   228034_x_at (Human Genome U133 Plus 2.0 Array)   234302_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000382091
Ensembl peptide - ENSP00000468116
NCBI entrez gene - 54890     See in Manteia.
OMIM - 613303
RefSeq - NM_017758
RefSeq Peptide - NP_060228
swissprot - Q6P6C2
swissprot - K7ER58
Ensembl - ENSG00000091542
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh5ENSDARG00000063003Danio rerio
 ALKBH5ENSGALG00000043693Gallus gallus
 Alkbh5ENSMUSG00000042650Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR032860  RNA demethylase ALKBH5
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair TAS
 biological_processGO:0006397 mRNA processing IMP
 biological_processGO:0006406 mRNA export from nucleus IMP
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035553 oxidative single-stranded RNA demethylation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0035515 oxidative RNA demethylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Reversal of alkylation damage by DNA dioxygenases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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