ENSG00000096433


Homo sapiens

Features
Gene ID: ENSG00000096433
  
Biological name :ITPR3
  
Synonyms : inositol 1,4,5-trisphosphate receptor type 3 / ITPR3 / Q14573
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.31
Gene start: 33620365
Gene end: 33696574
  
Corresponding Affymetrix probe sets: 201187_s_at (Human Genome U133 Plus 2.0 Array)   201188_s_at (Human Genome U133 Plus 2.0 Array)   201189_s_at (Human Genome U133 Plus 2.0 Array)   239542_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363435
Ensembl peptide - ENSP00000475177
NCBI entrez gene - 3710     See in Manteia.
OMIM - 147267
RefSeq - XM_011514577
RefSeq - NM_002224
RefSeq Peptide - NP_002215
swissprot - Q14573
Ensembl - ENSG00000096433
  
Related genetic diseases (OMIM): 222100 - {Diabetes, type 1, susceptibility to}, 222100
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpr3ENSDARG00000061741Danio rerio
 ITPR3ENSGALG00000003149Gallus gallus
 Itpr3ENSMUSG00000042644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITPR2 / Q14571 / inositol 1,4,5-trisphosphate receptor type 2ENSG0000012310465
ITPR1 / Q14643 / inositol 1,4,5-trisphosphate receptor type 1ENSG0000015099563
RYR1 / P21817 / ryanodine receptor 1ENSG0000019621824
RYR2 / Q92736 / ryanodine receptor 2ENSG0000019862624
RYR3 / Q15413 / ryanodine receptor 3ENSG0000019883823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000493  Inositol 1,4,5-trisphosphate receptor
 IPR000699  RIH domain
 IPR005821  Ion transport domain
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016093  MIR motif
 IPR035910  RyR/IP3 receptor binding core, RIH domain superfamily
 IPR036300  Mir domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007613 memory IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0050913 sensory perception of bitter taste IEA
 biological_processGO:0050916 sensory perception of sweet taste IEA
 biological_processGO:0050917 sensory perception of umami taste IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051291 protein heterooligomerization ISS
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060402 calcium ion transport into cytosol ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005640 nuclear outer membrane ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005903 brush border ISS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031095 platelet dense tubular network membrane TAS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043209 myelin sheath ISS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045177 apical part of cell ISS
 molecular_functionGO:0000822 inositol hexakisphosphate binding ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISS
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015278 calcium-release channel activity ISS
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0043533 inositol 1,3,4,5 tetrakisphosphate binding ISS
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IDA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
DAG and IP3 signaling
Role of phospholipids in phagocytosis
FCERI mediated Ca+2 mobilization
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Ca2+ pathway
Regulation of insulin secretion
VEGFR2 mediated cell proliferation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123104 ITPR2 / Q14571 / inositol 1,4,5-trisphosphate receptor type 2  / complex
 ENSG00000150995 ITPR1 / Q14643 / inositol 1,4,5-trisphosphate receptor type 1  / complex
 ENSG00000167323 STIM1 / Q13586 / stromal interaction molecule 1  / reaction
 ENSG00000168710 AHCYL1 / O43865 / adenosylhomocysteinase like 1  / complex / reaction
 ENSG00000096433 ITPR3 / Q14573 / inositol 1,4,5-trisphosphate receptor type 3  / complex






 

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