ENSDARG00000061741


Danio rerio

Features
Gene ID: ENSDARG00000061741
  
Biological name :itpr3
  
Synonyms : inositol 1,4,5-trisphosphate receptor, type 3 / itpr3
  
Possible biological names infered from orthology : P70227 / Q14573
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 21254192
Gene end: 21353035
  
Corresponding Affymetrix probe sets: Dr.23369.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000133340
Ensembl peptide - ENSDARP00000116513
Ensembl peptide - ENSDARP00000123064
NCBI entrez gene - 794666     See in Manteia.
RefSeq - NM_001313811
RefSeq - XM_017357379
RefSeq - XM_017357380
RefSeq Peptide - NP_001300740
swissprot - F1R1L5
swissprot - A0A0R4IH08
swissprot - F1Q5E3
ZFIN ID - ZDB-GENE-070605-1
Ensembl - ENSDARG00000061741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITPR3ENSGALG00000003149Gallus gallus
 ITPR3ENSG00000096433Homo sapiens
 Itpr3ENSMUSG00000042644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itpr1b / inositol 1,4,5-trisphosphate receptor, type 1b / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000007414962
itpr1a / inositol 1,4,5-trisphosphate receptor, type 1a / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000001465560
itpr2 / inositol 1,4,5-trisphosphate receptor, type 2 / Q14571* / Q9Z329*ENSDARG0000001190944
ryr1a / ryanodine receptor 1a (skeletal) / RYR1* / P21817* / E9PZQ0* / ryanodine receptor 1*ENSDARG0000001142222
ryr1b / ryanodine receptor 1b (skeletal) / RYR1* / P21817* / ryanodine receptor 1*ENSDARG0000002379722
ryr3 / ryanodine receptor 3 / A2AGL3* / Q15413*ENSDARG0000007133122
ryr2b / ryanodine receptor 2b (cardiac)ENSDARG0000000370621
RYR2 / ryanodine receptor 2 / Q92736*ENSDARG0000009885620
FO834850.1 / ITPR2* / Q14571* / inositol 1,4,5-trisphosphate receptor type 2*ENSDARG0000011126112
CABZ01083778.1ENSDARG000001154241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000493  Inositol 1,4,5-trisphosphate receptor
 IPR000699  RIH domain
 IPR005821  Ion transport domain
 IPR011989  Armadillo-like helical
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016024  Armadillo-type fold
 IPR016093  MIR motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000135 notochord notochord deformed , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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