ENSDARG00000023797


Danio rerio

Features
Gene ID: ENSDARG00000023797
  
Biological name :ryr1b
  
Synonyms : ryanodine receptor 1b (skeletal) / ryr1b
  
Possible biological names infered from orthology : E9PZQ0 / P21817 / ryanodine receptor 1 / RYR1
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 35491473
Gene end: 35736591
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000032856
NCBI entrez gene - 570245     See in Manteia.
RefSeq - NM_001102571
RefSeq Peptide - NP_001096041
swissprot - F1QEX9
ZFIN ID - ZDB-GENE-070705-417
Ensembl - ENSDARG00000023797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RYR1ENSG00000196218Homo sapiens
 Ryr1ENSMUSG00000030592Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ryr1a / ryanodine receptor 1a (skeletal) / RYR1* / P21817* / E9PZQ0* / ryanodine receptor 1*ENSDARG0000001142286
ryr3 / ryanodine receptor 3 / A2AGL3* / Q15413*ENSDARG0000007133163
RYR2 / ryanodine receptor 2 / Q92736*ENSDARG0000009885656
ryr2b / ryanodine receptor 2b (cardiac)ENSDARG0000000370654
itpr1a / inositol 1,4,5-trisphosphate receptor, type 1a / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000001465512
itpr3 / inositol 1,4,5-trisphosphate receptor, type 3 / P70227* / Q14573*ENSDARG0000006174112
itpr1b / inositol 1,4,5-trisphosphate receptor, type 1b / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000007414912
itpr2 / inositol 1,4,5-trisphosphate receptor, type 2 / Q14571* / Q9Z329*ENSDARG000000119099
CABZ01083778.1ENSDARG000001154244
FO834850.1 / ITPR2* / Q14571* / inositol 1,4,5-trisphosphate receptor type 2*ENSDARG000001112612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000699  RIH domain
 IPR001870  B30.2/SPRY domain
 IPR002048  EF-hand domain
 IPR003032  Ryanodine receptor Ryr
 IPR003877  SPRY domain
 IPR005821  Ion transport domain
 IPR009460  Ryanodine Receptor TM 4-6
 IPR011992  EF-hand domain pair
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013333  Ryanodine receptor
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016093  MIR motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0008345 larval locomotory behavior IMP
 biological_processGO:0031443 fast-twitch skeletal muscle fiber contraction IMP
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005219 ryanodine-sensitive calcium-release channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000473 trunk musculature trunk musculature fast muscle cell decreased contractility , abnormal
Show

 ZFA:0001056 myotome myotome fast muscle cell decreased functionality , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
Show

 ZFA:0001117 post-vent region post-vent region fast muscle cell decreased contractility , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle longitudinal sarcoplasmic reticulum swollen , abnormal
skeletal muscle myofibril disorganized , abnormal
skeletal muscle sarcoplasmic reticulum membrane dilated , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell sarcoplasmic reticulum disorganized , abnormal
fast muscle cell sarcoplasmic reticulum absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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