ENSDARG00000011909


Danio rerio

Features
Gene ID: ENSDARG00000011909
  
Biological name :itpr2
  
Synonyms : inositol 1,4,5-trisphosphate receptor, type 2 / itpr2
  
Possible biological names infered from orthology : Q14571 / Q9Z329
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 15937610
Gene end: 16042504
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000061133
Ensembl peptide - ENSDARP00000128737
swissprot - F1QW18
swissprot - X1WET6
ZFIN ID - ZDB-GENE-050419-192
Ensembl - ENSDARG00000011909
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITPR2ENSG00000123104Homo sapiens
 Itpr2ENSMUSG00000030287Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itpr1b / inositol 1,4,5-trisphosphate receptor, type 1b / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000007414964
itpr1a / inositol 1,4,5-trisphosphate receptor, type 1a / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000001465563
itpr3 / inositol 1,4,5-trisphosphate receptor, type 3 / P70227* / Q14573*ENSDARG0000006174158
ryr3 / ryanodine receptor 3 / A2AGL3* / Q15413*ENSDARG0000007133123
ryr1a / ryanodine receptor 1a (skeletal) / RYR1* / P21817* / E9PZQ0* / ryanodine receptor 1*ENSDARG0000001142222
ryr1b / ryanodine receptor 1b (skeletal) / RYR1* / P21817* / ryanodine receptor 1*ENSDARG0000002379722
ryr2b / ryanodine receptor 2b (cardiac)ENSDARG0000000370621
RYR2 / ryanodine receptor 2 / Q92736*ENSDARG0000009885621
FO834850.1 / ITPR2* / Q14571* / inositol 1,4,5-trisphosphate receptor type 2*ENSDARG000001112611
CABZ01083778.1ENSDARG000001154241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000493  Inositol 1,4,5-trisphosphate receptor
 IPR000699  RIH domain
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016093  MIR motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IBA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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