ENSG00000100601


Homo sapiens

Features
Gene ID: ENSG00000100601
  
Biological name :ALKBH1
  
Synonyms : ALKBH1 / alkB homolog 1, histone H2A dioxygenase / Q13686
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.3
Gene start: 77672404
Gene end: 77708020
  
Corresponding Affymetrix probe sets: 205621_at (Human Genome U133 Plus 2.0 Array)   236721_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451386
Ensembl peptide - ENSP00000451886
Ensembl peptide - ENSP00000216489
NCBI entrez gene - 8846     See in Manteia.
OMIM - 605345
RefSeq - NM_006020
RefSeq Peptide - NP_006011
swissprot - Q13686
swissprot - G3V4M4
swissprot - H0YJF3
Ensembl - ENSG00000100601
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh1ENSDARG00000071164Danio rerio
 ALKBH1ENSGALG00000010485Gallus gallus
 Alkbh1ENSMUSG00000079036Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004574  Alkylated DNA repair protein AlkB
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0002101 tRNA wobble cytosine modification IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair IDA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation IMP
 biological_processGO:0006448 regulation of translational elongation IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0035552 oxidative single-stranded DNA demethylation IBA
 biological_processGO:0042245 RNA repair IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070129 regulation of mitochondrial translation IMP
 biological_processGO:0070989 oxidative demethylation IDA
 biological_processGO:0080111 DNA demethylation IDA
 biological_processGO:1990983 tRNA demethylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000049 tRNA binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0008198 ferrous iron binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0043734 DNA-N1-methyladenine dioxygenase activity IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0070579 methylcytosine dioxygenase activity IDA
 molecular_functionGO:0103053 1-ethyladenine demethylase activity IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:1990984 tRNA demethylase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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