ENSG00000107807


Homo sapiens

Features
Gene ID: ENSG00000107807
  
Biological name :TLX1
  
Synonyms : P31314 / T cell leukemia homeobox 1 / TLX1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.31
Gene start: 101130505
Gene end: 101137789
  
Corresponding Affymetrix probe sets: 207179_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359215
Ensembl peptide - ENSP00000434358
Ensembl peptide - ENSP00000434914
NCBI entrez gene - 3195     See in Manteia.
OMIM - 186770
RefSeq - XM_011539745
RefSeq - NM_001195517
RefSeq - NM_005521
RefSeq - XM_011539744
RefSeq Peptide - NP_005512
RefSeq Peptide - NP_001182446
swissprot - P31314
swissprot - G3V1B7
Ensembl - ENSG00000107807
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlx1ENSDARG00000003965Danio rerio
 tlx2ENSDARG00000011273Danio rerio
 TLX1ENSGALG00000007831Gallus gallus
 Tlx1ENSMUSG00000025215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443858
TLX2 / O43763 / T cell leukemia homeobox 2ENSG0000011529752
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303222
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549220
NKX6-1 / P78426 / NK6 homeobox 1ENSG0000016362320
LBX1 / P52954 / ladybird homeobox 1ENSG0000013813619
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882618
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303917
HLX / Q14774 / H2.0 like homeoboxENSG0000013663017
HHEX / Q03014 / hematopoietically expressed homeoboxENSG0000015280417
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952817
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166816
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985115
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890914
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561013
A6NJ46 / NKX6-3 / NK6 homeobox 3ENSG000001650665


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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