ENSG00000163623


Homo sapiens

Features
Gene ID: ENSG00000163623
  
Biological name :NKX6-1
  
Synonyms : NK6 homeobox 1 / NKX6-1 / P78426
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.23
Gene start: 84491987
Gene end: 84498450
  
Corresponding Affymetrix probe sets: 221366_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295886
Ensembl peptide - ENSP00000449761
NCBI entrez gene - 4825     See in Manteia.
OMIM - 602563
RefSeq - NM_006168
RefSeq Peptide - NP_006159
swissprot - P78426
swissprot - F8VWZ9
Ensembl - ENSG00000163623
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx6.1ENSDARG00000022569Danio rerio
 NKX6-1ENSGALG00000032545Gallus gallus
 Nkx6-1ENSMUSG00000035187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882651
HLX / Q14774 / H2.0 like homeoboxENSG0000013663022
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985120
TLX1 / P31314 / T cell leukemia homeobox 1ENSG0000010780718
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443818
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303917
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549217
HHEX / Q03014 / hematopoietically expressed homeoboxENSG0000015280417
TLX2 / O43763 / T cell leukemia homeobox 2ENSG0000011529716
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166816
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303216
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561016
A6NJ46 / NKX6-3 / NK6 homeobox 3ENSG0000016506615
LBX1 / P52954 / ladybird homeobox 1ENSG0000013813614
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952814
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR033630  Homeobox protein NKX-6.1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IEA
 biological_processGO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0031016 pancreas development ISS
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045686 negative regulation of glial cell differentiation IEA
 biological_processGO:0045687 positive regulation of glial cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0051594 detection of glucose ISS
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0072560 type B pancreatic cell maturation ISS
 biological_processGO:2000078 positive regulation of type B pancreatic cell development ISS
 biological_processGO:2001222 regulation of neuron migration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression in beta cells
Regulation of gene expression in early pancreatic precursor cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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