ENSG00000111237


Homo sapiens
proteinendosomeVPS29transportmembranebindingintracellularwntretrograderetromercomplexionphosphodiesterasemjvpscalcineurin-likephosphoesterasedomainlpxhtypevacuolarsorting-associatedmetallo-dependentphosphatase-likesignalingpathwaygolgiplasmacytoplasmearlylate

Features
Gene ID: ENSG00000111237
  
Biological name :VPS29
  
Synonyms : Q9UBQ0 / VPS29 / VPS29, retromer complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.11
Gene start: 110491097
Gene end: 110502117
  
Corresponding Affymetrix probe sets: 1554388_at (Human Genome U133 Plus 2.0 Array)   223026_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480853
Ensembl peptide - ENSP00000449044
Ensembl peptide - ENSP00000449954
Ensembl peptide - ENSP00000353786
Ensembl peptide - ENSP00000400048
Ensembl peptide - ENSP00000447058
Ensembl peptide - ENSP00000447634
NCBI entrez gene - 51699     See in Manteia.
OMIM - 606932
RefSeq - XM_017019459
RefSeq - NM_001282150
RefSeq - NM_001282151
RefSeq - NM_016226
RefSeq - NM_057180
RefSeq - XM_006719459
RefSeq - XM_006719460
RefSeq - XM_011538484
RefSeq - XM_017019457
RefSeq Peptide - NP_001269079
RefSeq Peptide - NP_001269080
RefSeq Peptide - NP_057310
RefSeq Peptide - NP_476528
swissprot - Q9UBQ0
swissprot - F8VXU5
swissprot - Q05DG7
Ensembl - ENSG00000111237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps29ENSDARG00000069521Danio rerio
 VPS29ENSGALG00000004529Gallus gallus
 VPS29LENSGALG00000005951Gallus gallus
 Vps29ENSMUSG00000029462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000979  Phosphodiesterase MJ0936/Vps29
 IPR024654  Calcineurin-like phosphoesterase domain, lpxH type
 IPR028661  Vacuolar protein sorting-associated protein 29
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
macromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationestablishment of localizationcellular localizationcell communicationcellular response to stimulusmacromolecule localizationmacromolecule localizationestablishment of localizatioestablishment of localizationcellular localizationcellular localizationcell communicationcell communicationcellular response to stimulucellular response to stimulus
protein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingion bindingprotein transporter activityprotein bindingprotein bindingion bindingion bindingprotein transporter activityprotein transporter activity
cellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0030906 retromer, cargo-selective complex NAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122958 O75436 / VPS26A / VPS26, retromer complex component A  / complex
 ENSG00000112335 SNX3 / O60493 / sorting nexin 3  / complex / reaction
 ENSG00000116729 WLS / Q5T9L3 / wntless Wnt ligand secretion mediator  / complex / reaction
 ENSG00000069329 VPS35 / Q96QK1 / VPS35, retromer complex component  / complex






 

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