ENSG00000112335


Homo sapiens
bindingSNX3regulationproteinendosomemembranevesicleearlyphosphatidylinositol-transportwnt-phosphatedomainsignalingpathwayphoxhomologouspxsuperfamilyresponsebacteriuminvaginationneuronprojectiondevelopmentdeubiquitinationdockingcatabolicprocessviralentry

Features
Gene ID: ENSG00000112335
  
Biological name :SNX3
  
Synonyms : O60493 / SNX3 / sorting nexin 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 108211222
Gene end: 108261260
  
Corresponding Affymetrix probe sets: 200067_x_at (Human Genome U133 Plus 2.0 Array)   208781_x_at (Human Genome U133 Plus 2.0 Array)   210648_x_at (Human Genome U133 Plus 2.0 Array)   213545_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000230085
Ensembl peptide - ENSP00000296991
Ensembl peptide - ENSP00000357975
Ensembl peptide - ENSP00000401779
NCBI entrez gene - 8724     See in Manteia.
OMIM - 605930
RefSeq - NM_001300929
RefSeq - NM_001300928
RefSeq - NM_003795
RefSeq - NM_152827
RefSeq Peptide - NP_001287857
RefSeq Peptide - NP_001287858
RefSeq Peptide - NP_003786
RefSeq Peptide - NP_690040
swissprot - O60493
Ensembl - ENSG00000112335
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snx3ENSDARG00000008678Danio rerio
 SNX3ENSGALG00000015304Gallus gallus
 Snx3ENSMUSG00000019804Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SNX12 / Q9UMY4 / sorting nexin 12ENSG0000014716478
SNX11 / Q9Y5W9 / sorting nexin 11ENSG0000000291927
SNX10 / Q9Y5X0 / sorting nexin 10ENSG0000008630025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001683  Phox homologous domain
 IPR036871  PX domain superfamily


Gene Ontology (GO)
response to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponse to external stimulusresponse to biotic stimuluscellular component organizationanatomical structure developmentcellular developmental processmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processmembrane dockingcatabolic processinterspecies interaction between organismscellular localizationresponseresponse to external stimulusresponseresponse to biotic stimuluscellularcellular component organizationanatomicanatomical structure developmentcellularcellular developmental processmacromolmacromolecule localizationestablisestablishment of localizationcell comcell communicationcellularcellular response to stimulusnitrogennitrogen compound metabolic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processmembranemembrane dockingcatabolicatabolic processinterspeinterspecies interaction between organismscellularcellular localization
protein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindingprotein bindinglipid bindinglipid bindingion bindingion binding
cellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0010324 membrane invagination IDA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0022615 protein to membrane docking IDA
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0051224 negative regulation of protein transport IDA
 biological_processGO:0070676 intralumenal vesicle formation IMP
 biological_processGO:2000642 negative regulation of early endosome to late endosome transport IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane IBA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030904 retromer complex IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IDA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0010314 phosphatidylinositol-5-phosphate binding ISS
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding ISS
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISS


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103194 USP10 / Q14694 / ubiquitin specific peptidase 10  / complex
 ENSG00000122958 O75436 / VPS26A / VPS26, retromer complex component A  / complex / reaction
 ENSG00000116729 WLS / Q5T9L3 / wntless Wnt ligand secretion mediator  / complex / reaction
 ENSG00000069329 VPS35 / Q96QK1 / VPS35, retromer complex component  / complex / reaction
 ENSG00000111237 VPS29 / Q9UBQ0 / VPS29, retromer complex component  / complex / reaction






 

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