ENSG00000120068


Homo sapiens

Features
Gene ID: ENSG00000120068
  
Biological name :HOXB8
  
Synonyms : homeobox B8 / HOXB8 / P17481
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.32
Gene start: 48611377
Gene end: 48614939
  
Corresponding Affymetrix probe sets: 221278_at (Human Genome U133 Plus 2.0 Array)   229667_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000239144
Ensembl peptide - ENSP00000460254
Ensembl peptide - ENSP00000460659
NCBI entrez gene - 3218     See in Manteia.
OMIM - 142963
RefSeq - XM_017024564
RefSeq - NM_024016
RefSeq - XM_005257286
RefSeq Peptide - NP_076921
swissprot - P17481
swissprot - I3L3R1
swissprot - I3L383
Ensembl - ENSG00000120068
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxb8aENSDARG00000056027Danio rerio
 HOXB8ENSGALG00000040320Gallus gallus
 Hoxb8ENSMUSG00000056648Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOXD8 / P13378 / homeobox D8ENSG0000017587961
HOXC8 / P31273 / homeobox C8ENSG0000003796560
HOXB6 / P17509 / homeobox B6ENSG0000010851135
HOXA7 / P31268 / homeobox A7ENSG0000012259235
HOXA5 / P20719 / homeobox A5ENSG0000010600433
HOXA6 / P31267 / homeobox A6ENSG0000010600633
HOXB7 / P09629 / homeobox B7ENSG0000026002733
HOXC6 / P09630 / homeobox C6ENSG0000019775731
HOXB5 / P09067 / homeobox B5ENSG0000012007530
HOXD4 / P09016 / homeobox D4ENSG0000017016630
HOXC5 / Q00444 / homeobox C5ENSG0000017278929
HOXA4 / Q00056 / homeobox A4ENSG0000019757628
HOXC4 / P09017 / homeobox C4ENSG0000019835327
HOXB4 / P17483 / homeobox B4ENSG0000018274226
CDX2 / Q99626 / caudal type homeobox 2ENSG0000016555623
CDX1 / P47902 / caudal type homeobox 1ENSG0000011372222
CDX4 / O14627 / caudal type homeobox 4ENSG0000013126422
AC012531.3ENSG0000027304921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007625 grooming behavior IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0021516 dorsal spinal cord development IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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