ENSMUSG00000056648


Mus musculus

Features
Gene ID: ENSMUSG00000056648
  
Biological name :Hoxb8
  
Synonyms : Homeobox protein Hox-B8 / Hoxb8 / P09632
  
Possible biological names infered from orthology : homeobox B8 / P17481
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96281905
Gene end: 96285315
  
Corresponding Affymetrix probe sets: 10380629 (MoGene1.0st)   1452493_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052496
Ensembl peptide - ENSMUSP00000120351
Ensembl peptide - ENSMUSP00000128136
NCBI entrez gene - 15416     See in Manteia.
MGI - MGI:96189
RefSeq - XM_017314297
RefSeq - NM_010461
RefSeq - XM_011248758
RefSeq - XM_017314295
RefSeq - XM_017314296
RefSeq Peptide - NP_034591
swissprot - F6W0B3
swissprot - A2A9Z8
swissprot - P09632
Ensembl - ENSMUSG00000056648
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxb8aENSDARG00000056027Danio rerio
 HOXB8ENSGALG00000040320Gallus gallus
 HOXB8ENSG00000120068Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165761
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710260
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823637
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069035
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825333
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872133
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321933
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166131
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870030
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094229
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248529
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117429
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595629
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539427
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869226
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461922
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964622
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007625 grooming behavior IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
Show

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
Show

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8+
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitW-v/KitW-v
Genetic Background: C57BL/6J-KitW-v/J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Hoxb8tm4.1(cre/Esr1*)Mrc/Hoxb8tm4.1(cre/Esr1*)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.1Ble/Jak2tm1.1Ble
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Hoxb8tm2Jdes/Hoxb8tm2Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc,Hoxc8tm2.1(cre)Mrc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Kmmt/Ptch1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxd8tm1Jdes/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxc8tm1Phb/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004625 abnormal rib attachment "any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxc8tm1Phb/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1Jdes/Hoxb8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc,Hoxc8tm2.1(cre)Mrc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf14tm1Ddy/Tnfsf14tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0012283 decreased sternebra number "reduced average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hoxb8tm1Omm/Hoxb8tm1Omm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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