ENSMUSG00000038721


Mus musculus

Features
Gene ID: ENSMUSG00000038721
  
Biological name :Hoxb7
  
Synonyms : Homeobox protein Hox-B7 / Hoxb7 / P09024
  
Possible biological names infered from orthology : homeobox B7 / P09629
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 96286623
Gene end: 96290162
  
Corresponding Affymetrix probe sets: 10380634 (MoGene1.0st)   1427494_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040121
NCBI entrez gene - 15415     See in Manteia.
MGI - MGI:96188
RefSeq - NM_010460
RefSeq Peptide - NP_034590
swissprot - P09024
Ensembl - ENSMUSG00000038721
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HOXB7ENSGALG00000032740Gallus gallus
 HOXB7ENSG00000260027Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823659
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069048
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321941
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870040
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825338
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166137
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710237
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664837
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165736
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117436
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595636
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248535
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869235
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539435
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094234
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461928
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132625
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR017995  Homeobox protein, antennapedia type
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

Allelic Composition: Hoxa7tm1Mrc/Hoxa7tm1Mrc,Hoxb7tm1Mrc/Hoxb7+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Hoxa7tm1Mrc/Hoxa7+,Hoxb7tm1Mrc/Hoxb7tm1Mrc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Hoxa7tm1Mrc/Hoxa7tm1Mrc,Hoxb7tm1Mrc/Hoxb7tm1Mrc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Hoxa7tm1Mrc/Hoxa7tm1Mrc,Hoxb7tm1Mrc/Hoxb7tm1Mrc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0012283 decreased sternebra number "reduced average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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