ENSMUSG00000001657


Mus musculus

Features
Gene ID: ENSMUSG00000001657
  
Biological name :Hoxc8
  
Synonyms : Homeobox protein Hox-C8 / Hoxc8 / P09025
  
Possible biological names infered from orthology : homeobox C8 / P31273
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102990607
Gene end: 102994111
  
Corresponding Affymetrix probe sets: 10427290 (MoGene1.0st)   1452412_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001703
NCBI entrez gene - 15426     See in Manteia.
MGI - MGI:96198
RefSeq - NM_010466
RefSeq Peptide - NP_034596
swissprot - P09025
Ensembl - ENSMUSG00000001657
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hoxc8aENSDARG00000070346Danio rerio
 HOXC8ENSGALG00000037262Gallus gallus
 HOXC8ENSG00000037965Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710261
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664861
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823636
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069033
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872133
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166131
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825331
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870031
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321931
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117429
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595629
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248527
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539427
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869226
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094225
Cdx1 / P18111 / Homeobox protein CDX-1 / P47902* / caudal type homeobox 1*ENSMUSG0000002461922
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964622
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR001827  Homeobox protein, antennapedia type, conserved site
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxc8tm2Jepl/Hoxc8tm2Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm2Jepl/Hoxc8+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm4(Hoxc9)Jepl/Hoxc8tm4(Hoxc9)Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm4(Hoxc9)Jepl/Hoxc8+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc,Hoxc8tm2.1(cre)Mrc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxc8tm1Phb/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003807 camptodactyly "permanant flexion of one or more digits; contractures may also be seen in the wrists and at the elbows" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm2Jepl/Hoxc8tm2Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm2Jepl/Hoxc8+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm4(Hoxc9)Jepl/Hoxc8tm4(Hoxc9)Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm4(Hoxc9)Jepl/Hoxc8+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxc8tm1Phb/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm1.1Rud/Hoxc8tm1.1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/?
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004625 abnormal rib attachment "any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/Hoxb8tm1.1Jdes,Hoxc8tm1Phb/?
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8tm3.1(IRES-rtTA2*M2)Mrc,Hoxc8tm2.1(cre)Mrc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1.1Jdes/?,Hoxc8tm1Phb/Hoxc8tm1Phb,Hoxd8tm1Jdes/Hoxd8tm1Jdes
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm2Jepl/Hoxc8tm2Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm2Jepl/Hoxc8+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm3(Hoxc9)Jepl/Hoxc8tm3(Hoxc9)Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm4(Hoxc9)Jepl/Hoxc8tm4(Hoxc9)Jepl
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hoxc8tm4(Hoxc9)Jepl/Hoxc8+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0012284 increased sternebra number "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hoxc8tm1Rud/Hoxc8tm1Rud
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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