ENSMUSG00000024619


Mus musculus

Features
Gene ID: ENSMUSG00000024619
  
Biological name :Cdx1
  
Synonyms : Cdx1 / Homeobox protein CDX-1 / P18111
  
Possible biological names infered from orthology : caudal type homeobox 1 / P47902
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E1
Gene start: 61018862
Gene end: 61036199
  
Corresponding Affymetrix probe sets: 10459153 (MoGene1.0st)   1449582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025521
NCBI entrez gene - 12590     See in Manteia.
MGI - MGI:88360
RefSeq - NM_009880
RefSeq Peptide - NP_034010
swissprot - P18111
Ensembl - ENSMUSG00000024619
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdx1aENSDARG00000114554Danio rerio
 CDX1ENSGALG00000005679Gallus gallus
 CDX1ENSG00000113722Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdx2 / P43241 / Homeobox protein CDX-2 / Q99626* / caudal type homeobox 2*ENSMUSG0000002964649
Cdx4 / Q07424 / Homeobox protein CDX-4 / O14627* / caudal type homeobox 4*ENSMUSG0000003132641
Hoxb6 / P09023 / Homeobox protein Hox-B6 / P17509* / homeobox B6*ENSMUSG0000000069024
Hoxb4 / P10284 / Homeobox protein Hox-B4 / P17483* / homeobox B4*ENSMUSG0000003869224
Hoxb5 / P09079 / Homeobox protein Hox-B5 / P09067* / homeobox B5*ENSMUSG0000003870024
Hoxc4 / Q08624 / homeobox C4 / P09017*ENSMUSG0000007539424
Hoxb7 / P09024 / Homeobox protein Hox-B7 / P09629* / homeobox B7*ENSMUSG0000003872123
Hoxa4 / homeobox A4 / Q00056*ENSMUSG0000000094222
Hoxc5 / P32043 / Homeobox protein Hox-C5 / Q00444* / homeobox C5*ENSMUSG0000002248522
Hoxa7 / P02830 / homeobox A7 / P31268*ENSMUSG0000003823622
Hoxa6 / P09092 / Homeobox protein Hox-A6 / P31267* / homeobox A6*ENSMUSG0000004321922
Hoxd8 / P23463 / Homeobox protein Hox-D8 / P13378* / homeobox D8*ENSMUSG0000002710221
Hoxa5 / P09021 / Homeobox protein Hox-A5 / P20719* / homeobox A5*ENSMUSG0000003825321
Hoxd4 / P10628 / homeobox D4 / P09016*ENSMUSG0000010117421
Hoxd4 / P10628 / Homeobox protein Hox-D4 / P09016* / homeobox D4*ENSMUSG0000011595621
Hoxc8 / P09025 / Homeobox protein Hox-C8 / P31273* / homeobox C8*ENSMUSG0000000165720
Hoxc6 / P10629 / Homeobox protein Hox-C6 / P09630* / homeobox C6*ENSMUSG0000000166120
Hoxb8 / P09632 / Homeobox protein Hox-B8 / P17481* / homeobox B8*ENSMUSG0000005664820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR006820  Caudal-like activation domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0009948 anterior/posterior axis specification IBA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0014807 regulation of somitogenesis IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060349 bone morphogenesis IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000080 abnormal exoccipital bone morphology "malformed lateral part of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm2Lhn/Cdx1tm2Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000151 absent rib "missing the pairs of bony structures that make up the body wall" [J:19212]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1+
Genetic Background: involves: 129 * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdx2tm2Fbe/Cdx2tm2Fbe,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mogat2tm1Far/Mogat2+
Genetic Background: B6.129S4-Mogat2tm1Far

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm2Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm2Lhn/Cdx1tm2Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
Genetic Background: involves: 129 * C57BL/6

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm2Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm2Lhn/Cdx1tm2Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
Genetic Background: involves: 129 * C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1+,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm2Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm2Lhn/Cdx1tm2Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Cdx4tm1.1Jdes/Y
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0004658 abnormal ventral tubercle of atlas "any structural anomaly of the conical ventral projection on the arch of the atlas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Pgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn,Rargtm1Ipc/Rarg+
Genetic Background: involves: 129 * C57BL/6

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdx1tm2Lhn/Cdx1tm2Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdx1tm3Lhn/Cdx1tm3Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009784 abnormal melanoblast migration "defect in the dispersion of the cells that originate from the neural crest and differentiate into pigment cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr,Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdx1tm1Lhn/Cdx1tm1Lhn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030282 broad supraoccipital bone "increased width of the bone on the dorsal side of the great foramen of the skull, which usually forms a part of the occipital in the adult, but is distinct in the young" [MGI:anna]
Show

Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdx1tm1Pgr/Cdx1tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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