ENSG00000125851


Homo sapiens

Features
Gene ID: ENSG00000125851
  
Biological name :PCSK2
  
Synonyms : P16519 / PCSK2 / proprotein convertase subtilisin/kexin type 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p12.1
Gene start: 17226107
Gene end: 17484578
  
Corresponding Affymetrix probe sets: 204869_at (Human Genome U133 Plus 2.0 Array)   204870_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262545
Ensembl peptide - ENSP00000367131
Ensembl peptide - ENSP00000437458
NCBI entrez gene - 5126     See in Manteia.
OMIM - 162151
RefSeq - NM_001201529
RefSeq - NM_001201528
RefSeq - NM_002594
RefSeq Peptide - NP_001188457
RefSeq Peptide - NP_001188458
RefSeq Peptide - NP_002585
swissprot - P16519
Ensembl - ENSG00000125851
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk2ENSDARG00000019451Danio rerio
 PCSK2ENSGALG00000008734Gallus gallus
 Pcsk2ENSMUSG00000027419Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FURIN / P09958 / furin, paired basic amino acid cleaving enzymeENSG0000014056445
PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1ENSG0000017542644
PCSK6 / P29122 / proprotein convertase subtilisin/kexin type 6ENSG0000014047943
PCSK5 / Q92824 / proprotein convertase subtilisin/kexin type 5ENSG0000009913942
PCSK4 / Q6UW60 / proprotein convertase subtilisin/kexin type 4ENSG0000011525742
PCSK7 / Q16549 / proprotein convertase subtilisin/kexin type 7ENSG0000016061335


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016486 peptide hormone processing IDA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0030070 insulin processing IDA
 biological_processGO:0034230 enkephalin processing ISS
 biological_processGO:0034231 islet amyloid polypeptide processing ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Insulin processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000254647 INS / P01308 / insulin  / reaction






 

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