ENSG00000126215


Homo sapiens

Features
Gene ID: ENSG00000126215
  
Biological name :XRCC3
  
Synonyms : O43542 / X-ray repair cross complementing 3 / XRCC3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 103697609
Gene end: 103715504
  
Corresponding Affymetrix probe sets: 216299_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473569
Ensembl peptide - ENSP00000452389
Ensembl peptide - ENSP00000452598
Ensembl peptide - ENSP00000343392
Ensembl peptide - ENSP00000450738
Ensembl peptide - ENSP00000450780
Ensembl peptide - ENSP00000451118
Ensembl peptide - ENSP00000451173
Ensembl peptide - ENSP00000451252
Ensembl peptide - ENSP00000451361
Ensembl peptide - ENSP00000451362
Ensembl peptide - ENSP00000451974
NCBI entrez gene - 7517     See in Manteia.
OMIM - 600675
RefSeq - XM_011537138
RefSeq - NM_001100118
RefSeq - NM_001100119
RefSeq - NM_005432
RefSeq - XM_005268046
RefSeq Peptide - NP_001093589
RefSeq Peptide - NP_005423
RefSeq Peptide - NP_001093588
swissprot - Q53XC8
swissprot - G3V2L7
swissprot - G3V2P3
swissprot - G3V399
swissprot - G3V3C8
swissprot - G3V3Q2
swissprot - G3V3H9
swissprot - G3V5K0
swissprot - O43542
Ensembl - ENSG00000126215
  
Related genetic diseases (OMIM): 114480 - {Breast cancer, susceptibility to}, 114480
  613972 - {Melanoma, cutaneous malignant, 6}, 613972
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc3ENSDARG00000017928Danio rerio
 XRCC3ENSGALG00000011533Gallus gallus
 Xrcc3ENSMUSG00000021287Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43502 / RAD51C / RAD51 paralog CENSG0000010838425
O15315 / RAD51B / RAD51 paralog BENSG0000018218525
O75771 / RAD51D / RAD51 paralog DENSG0000018537920


Protein motifs (from Interpro)
Interpro ID Name
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033925  Rad51/DMC1/RadA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000707 meiotic DNA recombinase assembly IBA
 biological_processGO:0000722 telomere maintenance via recombination IMP
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0000731 DNA synthesis involved in DNA repair TAS
 biological_processGO:0000732 strand displacement TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus TAS
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0036297 interstrand cross-link repair IMP
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0071140 resolution of mitotic recombination intermediates IMP
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
 biological_processGO:0090656 t-circle formation IMP
 biological_processGO:0090657 telomeric loop disassembly TAS
 biological_processGO:0090737 telomere maintenance via telomere trimming IGI
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IC
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
 cellular_componentGO:0033065 Rad51C-XRCC3 complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000400 four-way junction DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IMP


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132207 SLX1A / Q9BQ83 / SLX1 homolog A, structure-specific endonuclease subunit  / reaction
 ENSG00000175643 RMI2 / Q96E14 / RecQ mediated genome instability 2  / reaction
 ENSG00000172732 MUS81 / Q96NY9 / MUS81 structure-specific endonuclease subunit  / reaction
 ENSG00000188827 SLX4 / Q8IY92 / SLX4 structure-specific endonuclease subunit  / reaction
 ENSG00000178966 RMI1 / Q9H9A7 / RecQ mediated genome instability 1  / reaction
 ENSG00000154920 EME1 / Q96AY2 / essential meiotic structure-specific endonuclease 1  / reaction
 ENSG00000177302 TOP3A / Q13472 / DNA topoisomerase III alpha  / reaction
 ENSG00000178295 GEN1 / Q17RS7 / GEN1, Holliday junction 5 flap endonuclease  / reaction
 ENSG00000258366 RTEL1 / Q9NZ71 / regulator of telomere elongation helicase 1  / reaction
 ENSG00000108384 O43502 / RAD51C / RAD51 paralog C  / complex / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / reaction






 

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