ENSGALG00000011533


Gallus gallus

Features
Gene ID: ENSGALG00000011533
  
Biological name :XRCC3
  
Synonyms : X-ray repair cross complementing 3 / XRCC3
  
Possible biological names infered from orthology : O43542 / Q9CXE6 / X-ray repair complementing defective repair in Chinese hamster cells 3
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 50552442
Gene end: 50561187
  
Corresponding Affymetrix probe sets: Gga.3684.1.S1_s_at (Chicken Array)   GgaAffx.11661.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059641
Ensembl peptide - ENSGALP00000064003
Ensembl peptide - ENSGALP00000062264
Ensembl peptide - ENSGALP00000031860
Ensembl peptide - ENSGALP00000043797
Ensembl peptide - ENSGALP00000048206
NCBI entrez gene - 423485     See in Manteia.
RefSeq - NM_001006489
RefSeq - XM_015287481
RefSeq Peptide - NP_001006489
swissprot - F7BE57
swissprot - A0A1D5P682
swissprot - Q5ZM26
swissprot - A0A1D5NTZ0
Ensembl - ENSGALG00000011533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrcc3ENSDARG00000017928Danio rerio
 XRCC3ENSG00000126215Homo sapiens
 Xrcc3ENSMUSG00000021287Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAD51C / RAD51 paralog C / O43502* / Q924H5* / DNA repair 3 *ENSGALG0000004038023
RAD51B / RAD51 paralog B / O15315* / O35719* / DNA repair 2 *ENSGALG0000000949119
RAD51D / RAD51 paralog D / O55230* / O75771*ENSGALG0000003191817


Protein motifs (from Interpro)
Interpro ID Name
 IPR013632  DNA recombination and repair protein Rad51-like, C-terminal
 IPR016467  DNA recombination and repair protein, RecA-like
 IPR020588  DNA recombination and repair protein RecA-like, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000707 meiotic DNA recombinase assembly IBA
 biological_processGO:0000722 telomere maintenance via recombination IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0007131 reciprocal meiotic recombination IBA
 biological_processGO:0010212 response to ionizing radiation IBA
 biological_processGO:0010824 regulation of centrosome duplication IEA
 biological_processGO:0036297 interstrand cross-link repair IEA
 biological_processGO:0042148 strand invasion IBA
 biological_processGO:0071140 resolution of mitotic recombination intermediates IEA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:0090656 t-circle formation IEA
 biological_processGO:0090737 telomere maintenance via telomere trimming IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
 cellular_componentGO:0033065 Rad51C-XRCC3 complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000150 recombinase activity IBA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006123 RTEL1* / Q0VGM9* / Q9NZ71* / RTEL1-TNFRSF6B* / RTEL1-TNFRSF6B readthrough (NMD candidate)* / regulator of telomere elongation helicase 1*  / reaction
 ENSGALG00000040380 RAD51C / RAD51 paralog C / O43502* / Q924H5* / DNA repair 3 *  / complex / reaction
 ENSGALG00000031841 SLX4 / SLX4 structure-specific endonuclease subunit / Q6P1D7* / Q8IY92* / Structure-specific endonuclease subunit SLX4 *  / reaction






 

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