ENSG00000129455


Homo sapiens

Features
Gene ID: ENSG00000129455
  
Biological name :KLK8
  
Synonyms : kallikrein related peptidase 8 / KLK8 / O60259
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.41
Gene start: 50996007
Gene end: 51002711
  
Corresponding Affymetrix probe sets: 1552319_a_at (Human Genome U133 Plus 2.0 Array)   206125_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472273
Ensembl peptide - ENSP00000472016
Ensembl peptide - ENSP00000473067
Ensembl peptide - ENSP00000291726
Ensembl peptide - ENSP00000325072
Ensembl peptide - ENSP00000341555
Ensembl peptide - ENSP00000375682
Ensembl peptide - ENSP00000469278
NCBI entrez gene - 11202     See in Manteia.
OMIM - 605644
RefSeq - NM_007196
RefSeq - NM_144506
RefSeq - NM_144507
RefSeq - NM_001281431
RefSeq - NM_144505
RefSeq Peptide - NP_009127
RefSeq Peptide - NP_653089
RefSeq Peptide - NP_653090
RefSeq Peptide - NP_001268360
RefSeq Peptide - NP_653088
swissprot - O60259
swissprot - A0A0A0MQY9
swissprot - M0R231
swissprot - M0R390
Ensembl - ENSG00000129455
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Klk8ENSMUSG00000064023Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLK14 / Q9P0G3 / kallikrein related peptidase 14ENSG0000012943742
KLK11 / Q9UBX7 / kallikrein related peptidase 11ENSG0000016775740
KLK13 / Q9UKR3 / kallikrein related peptidase 13ENSG0000016775940
KLK15 / Q9H2R5 / kallikrein related peptidase 15ENSG0000017456239
KLK9 / Q9UKQ9 / kallikrein related peptidase 9ENSG0000021302239
AC011473.4ENSG0000026974139
KLK6 / Q92876 / kallikrein related peptidase 6ENSG0000016775536
PRSS1 / P07477 / serine protease 1ENSG0000020498333
PRSS2 / P07478 / serine protease 2ENSG0000027589633
PRSS3 / P35030 / serine protease 3ENSG0000001043832


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007613 memory ISS
 biological_processGO:0008219 cell death ISS
 biological_processGO:0009611 response to wounding ISS
 biological_processGO:0031642 negative regulation of myelination ISS
 biological_processGO:0043616 keratinocyte proliferation ISS
 biological_processGO:0048681 negative regulation of axon regeneration ISS
 biological_processGO:0048812 neuron projection morphogenesis ISS
 biological_processGO:0050807 regulation of synapse organization ISS
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0070268 cornification TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0097180 serine protease inhibitor complex IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167754 KLK5 / Q9Y337 / kallikrein related peptidase 5  / reaction






 

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