ENSMUSG00000064023


Mus musculus

Features
Gene ID: ENSMUSG00000064023
  
Biological name :Klk8
  
Synonyms : Kallikrein-8 / Klk8 / Q61955
  
Possible biological names infered from orthology : kallikrein related peptidase 8 / O60259
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 43797577
Gene end: 43803826
  
Corresponding Affymetrix probe sets: 10552500 (MoGene1.0st)   1419722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145580
Ensembl peptide - ENSMUSP00000082588
NCBI entrez gene - 259277     See in Manteia.
MGI - MGI:1343327
RefSeq - XM_017322279
RefSeq - NM_001324398
RefSeq - NM_008940
RefSeq Peptide - NP_001311327
RefSeq Peptide - NP_032966
swissprot - A0A0B6VRH9
swissprot - A0A0U1RNI7
swissprot - Q61955
Ensembl - ENSMUSG00000064023
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLK8ENSG00000129455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klk11 / Q9QYN3 / Kallikrein-11 / Q9UBX7* / kallikrein related peptidase 11*ENSMUSG0000006761647
Klk15 / kallikrein related peptidase 15 / Q9H2R5*ENSMUSG0000005519346
Klk13 / kallikrein related-peptidase 13 / Q9UKR3*ENSMUSG0000005404645
Klk14 / Q8CGR5 / Kallikrein-14 / Q9P0G3* / kallikrein related peptidase 14*ENSMUSG0000004473744
Klk9 / Q9UKQ9* / AC011473.4* / kallikrein related peptidase 9*ENSMUSG0000004788444
Klk6 / kallikrein related peptidase 6 / Q92876*ENSMUSG0000005006342
Prss2 / P07146 / protease, serine 2 / PRSS1* / PRSS3* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000005716341
Prss1 / PRSS2* / PRSS3* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000006275141
2210010C04Rik / RIKEN cDNA 2210010C04 geneENSMUSG0000002988240
Try5 / PRSS2* / PRSS3* / PRSS1* / P07477* / P35030* / P07478* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000003693840
Try4 / trypsin 4 / PRSS3* / PRSS1* / PRSS2* / P35030* / P07478* / P07477* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000005410640
Gm5771 / PRSS1* / PRSS2* / PRSS3* / P07477* / P07478* / P35030* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000005811940
Gm10334 / PRSS1* / PRSS2* / PRSS3* / P07477* / P07478* / P35030* / serine protease 2* / serine protease 3* / serine protease 1*ENSMUSG0000007151740
Prss3 / PRSS2* / PRSS1* / P07478* / P07477* / P35030* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000007151940
Try10 / trypsin 10 / PRSS3* / PRSS1* / PRSS2* / P35030* / P07478* / P07477* / serine protease 3* / serine protease 1* / serine protease 2*ENSMUSG0000007152140
1810009J06Rik / RIKEN cDNA 1810009J06 geneENSMUSG0000009480840
Gm2663ENSMUSG0000009652540
Gm4744ENSMUSG0000006325227


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0008219 cell death IMP
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0031642 negative regulation of myelination IMP
 biological_processGO:0043616 keratinocyte proliferation IMP
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0050807 regulation of synapse organization IMP
 biological_processGO:0050808 synapse organization IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0097180 serine protease inhibitor complex ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab27aash/Rab27aash,Rab27btm1Tiz/Rab27btm1Tiz
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074155 Klk5 / kallikrein related-peptidase 5 / Q9Y337*  / reaction






 

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