ENSG00000137760


Homo sapiens

Features
Gene ID: ENSG00000137760
  
Biological name :ALKBH8
  
Synonyms : ALKBH8 / alkB homolog 8, tRNA methyltransferase / Q96BT7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.3
Gene start: 107502726
Gene end: 107565746
  
Corresponding Affymetrix probe sets: 235610_at (Human Genome U133 Plus 2.0 Array)   235713_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397673
Ensembl peptide - ENSP00000391225
Ensembl peptide - ENSP00000415885
Ensembl peptide - ENSP00000260318
Ensembl peptide - ENSP00000374219
Ensembl peptide - ENSP00000376812
NCBI entrez gene - 91801     See in Manteia.
OMIM - 613306
RefSeq - XM_017018557
RefSeq - NM_001301010
RefSeq - NM_138775
RefSeq - XM_017018553
RefSeq - XM_017018554
RefSeq - XM_017018555
RefSeq - XM_017018556
RefSeq - XM_005271728
RefSeq - XM_005271729
RefSeq Peptide - NP_001287939
RefSeq Peptide - NP_620130
swissprot - Q96BT7
swissprot - C9JQN2
Ensembl - ENSG00000137760
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh8ENSDARG00000060256Danio rerio
 ALKBH8ENSGALG00000017170Gallus gallus
 Alkbh8ENSMUSG00000025899Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9P272 / TRMT9B / tRNA methyltransferase 9B (putative)ENSG0000025030516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR013216  Methyltransferase type 11
 IPR015095  Alkylated DNA repair protein AlkB, homologue 8, N-terminal
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR032863  Alkylated DNA repair protein alkB homologue 8
 IPR034256  ALKBH8, RNA recognition motif
 IPR035979  RNA-binding domain superfamily
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002098 tRNA wobble uridine modification IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030488 tRNA methylation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000049 tRNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008198 ferrous iron binding IBA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016300 tRNA (uracil) methyltransferase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
tRNA modification in the nucleus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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